RASSF1 - Ras association domain family member 1 Gene
Also Known as 123F2; RDA32; NORE2A; RASSF1A; REH3P21
Species: Homo sapiens
About RASSF1
This gene has 10 transcripts (splice variants), 274 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.8), spleen (RPKM 15.6) and 25 other tissues.
Summary
This gene encodes a protein similar to the Ras effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
RASSF1 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001206957.2 | NP_001193886.1 | ras association domain-containing protein 1 isoform B |
| NM_007182.5 | NP_009113.3 | ras association domain-containing protein 1 isoform A |
| NM_170712.3 | NP_733830.1 | ras association domain-containing protein 1 isoform B |
| NM_170713.3 | NP_733831.1 | ras association domain-containing protein 1 isoform C |
| NM_170714.2 | NP_733832.1 | ras association domain-containing protein 1 isoform D |
| Molecular Function GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
11857081 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11857081 | GOA |
| Biological Process GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| involved in DNA damage response |
IMP
IMP: Inferred from mutant phenotype
|
18566590 | GOA |
| involved in Ras protein signal transduction |
IDA
IDA: Inferred from direct assay
|
15109305 | GOA |
| involved in positive regulation of protein ubiquitination |
IDA
IDA: Inferred from direct assay
|
18566590 | GOA |
| involved in protein stabilization |
IDA
IDA: Inferred from direct assay
|
18566590 | GOA |
| involved in regulation of cell cycle |
IDA
IDA: Inferred from direct assay
|
18566590 | GOA |
| acts upstream of negative effect regulation of cell cycle G1/S phase transition |
IMP
IMP: Inferred from mutant phenotype
|
12024041 | GOA |
| Cellular Component GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| located in microtubule cytoskeleton |
IDA
IDA: Inferred from direct assay
|
14743218 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
14743218 | GOA |
RASSF1 Protein Structure
C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (52 - 105)
RA: Ras association (RalGDS/AF-6) domain (208 - 291)
- 0
- 100
- 200
- 300
- 344 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ras association domain-containing protein 1 |
|
RASSF1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Referencias |
|---|---|---|---|---|---|---|---|
|
Intra
|
RASSF1 | Q9NS23 | MAP1LC3C | Homo sapiens | Q9BXW4 | 20562859 | |
|
Intra
|
RASSF1 | Q9NS23 | SUV39H1 | Homo sapiens | O43463 | 23455924 | |
|
Intra
|
RASSF1 | Q9NS23 | SUV39H1 | Homo sapiens | O43463 | 23455924 | |
|
Intra
|
RASSF1 | Q9NS23 | MAP1LC3B | Homo sapiens | Q9GZQ8 | 20562859 | |
|
Intra
|
RASSF1 | Q9NS23 | MDM2 | Homo sapiens | Q00987 | 18566590 | |
|
Intra
|
RASSF1 | Q9NS23 | KDM1A | Homo sapiens | O60341 | 23455924 | |
|
Intra
|
RASSF1 | Q9NS23 | GABARAP | Homo sapiens | O95166 | 20562859 | |
|
Intra
|
RASSF1 | Q9NS23 | GABARAPL2 | Homo sapiens | P60520 | 20562859 |
RASSF1 Antibodies
| Referencia número | Nombre del producto | Aplicación | Reactivity |
|---|---|---|---|
| HY-P85464 | RASSF1 Antibody (YA5156) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cervical Adenocarcinoma |
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| Cervical Squamous Cell Carcinoma |
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| Endometrial Cancer |
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| Bladder Cancer |
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| Seminoma |
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| Breast Fibroadenoma |
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| Lung Cancer |
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| Nasopharyngeal Carcinoma |
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| Lung Benign Neoplasm |
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| Papilloma |
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| Adenoid Cystic Carcinoma |
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| Renal Cell Carcinoma, Nonpapillary |
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| Kidney Cancer |
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| Medulloblastoma |
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| Cholecystitis |
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| Hepatocellular Adenoma |
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| Penile Cancer |
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| Von Hippel-Lindau Syndrome |
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| Mesothelioma, Malignant |
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| Colorectal Cancer |
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| Breast Cancer |
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| Cervical Cancer |
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| Gastric Cancer |
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| Cholangiocarcinoma |
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| Intracranial Primitive Neuroectodermal Tumor |
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| Ovarian Cancer |
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| Ewing Sarcoma |
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| Hepatoblastoma |
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| Hepatocellular Carcinoma |
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| Lung Cancer Susceptibility 3 |
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| Prostate Cancer |
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| Sarcoma, Synovial |
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| Spinocerebellar Ataxia, X-Linked 3 |
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| Spinocerebellar Ataxia, X-Linked 4 |
|
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| Squamous Cell Carcinoma, Head And Neck |
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| Melanoma |
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| Neuroblastoma |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | RASSF1 | RGD | RGD:1359383 |
| Bos taurus | RASSF1 | VGNC | VGNC:33757 |
| Canis familiaris | RASSF1 | VGNC | VGNC:45378 |
| Mus musculus | RASSF1 | MGD | MGI:1928386 |
| Felis catus | RASSF1 | VGNC | VGNC:69252 |
| Macaca mulatta | RASSF1 | VGNC | VGNC:76673 |
| Others | RASSF1 | NCBI |