MACROD1 - mono-ADP ribosylhydrolase 1 Gene

Also Known as LRP16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28992

About MACROD1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,998,558-64,166,113 (from NCBI)

This gene has 8 transcripts (splice variants), 170 orthologues and 2 paralogues. Broad expression in kidney (RPKM 9.5), prostate (RPKM 2.7) and 22 other tissues.

Summary

Enables ADP-ribosylglutamate hydrolase activity and deacetylase activity. Involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MACROD1 Products (2)

mRNA	Protein	Name
NM_001411019.1	NP_001397948.1	ADP-ribose glycohydrolase MACROD1 isoform 2
NM_014067.4	NP_054786.2	ADP-ribose glycohydrolase MACROD1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables ADP-ribosylglutamate hydrolase activity	IDA IDA: Inferred from direct assay	23474714	GOA
enables deacetylase activity	IDA IDA: Inferred from direct assay	21257746	GOA
enables hydrolase activity, acting on glycosyl bonds	IDA IDA: Inferred from direct assay	23474712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17914104	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23474712	GOA
involved in peptidyl-glutamate ADP-deribosylation	IDA IDA: Inferred from direct assay	23474714	GOA
involved in protein de-ADP-ribosylation	IDA IDA: Inferred from direct assay	23474712	GOA
involved in purine nucleoside metabolic process	IDA IDA: Inferred from direct assay	21257746	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in nucleus	IDA IDA: Inferred from direct assay	23474712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MACROD1 Protein Structure

Macro

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
ADP-ribose glycohydrolase MACROD1	MACRO domain containing 1

MACROD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	MACROD1	Q9BQ69	KRT18	Homo sapiens	P05783	Anti Bait CoIP	20035625
Intra	MACROD1	Q9BQ69	KRT18	Homo sapiens	P05783	Y2H	20035625
Intra	MACROD1	Q9BQ69	KRT18	Homo sapiens	P05783	Pull Down	20035625
Intra	MACROD1	Q9BQ69	PARP1	Homo sapiens	P09874	Anti Tag CoIP	33961781
Intra	MACROD1	Q9BQ69	PARP1	Homo sapiens	P09874	Anti Tag CoIP	28514442
Intra	MACROD1	Q9BQ69	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	32296183
Intra	MACROD1	Q9BQ69	KPNA1	Homo sapiens	P52294	Y2H Array	32296183
Intra	MACROD1	Q9BQ69	RELA	Homo sapiens	Q04206	Pull Down	21483817
Intra	MACROD1	Q9BQ69	ESR1	Homo sapiens	P03372	Anti Bait CoIP	17914104
Intra	MACROD1	Q9BQ69	ESR1	Homo sapiens	P03372	Pull Down	17914104
Intra	MACROD1	Q9BQ69	ESR1	Homo sapiens	P03372	Anti Bait CoIP	20035625

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-146248B	TFMU-ADPr diammonium		98.78%	Unkown
HY-146248	TFMU-ADPr		/	Unkown
HY-RS07945	MACROD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MACROD1	VGNC	VGNC:107456
Bos taurus	MACROD1	VGNC	VGNC:56272
Mus musculus	MACROD1	MGD	MGI:2147583
Felis catus	MACROD1	VGNC	VGNC:103132
Canis familiaris	MACROD1	VGNC	VGNC:51880
Rattus norvegicus	MACROD1	RGD	RGD:628701
Others	MACROD1	NCBI