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Referencia número: HY-P99658A

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Imaprelimab (powder)

Imaprelimab (powder) is a humanized IgG1κ anti-CD146 antibody. Imaprelimab (powder) exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab (powder) can be used in studies related to brain metastasis of non-small cell lung cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Imaprelimab (powder) Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Bioz

Actividad biológica

Descripciòn

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

In Vivo

Imaprelimab (10 mg/kg; i.p.; every two days; 21 days) exerts stronger anti-tumor and anti-angiogenic effects than Bevacizumab (HY-P9906) in a subcutaneous non-small cell lung carcinoma brain metastasis mouse model^[1].
Imaprelimab (10 mg/kg; i.p.; every two days; 3 weeks) inhibits intracranial non-small cell lung carcinoma brain metastasis growth and angiogenesis more potently than Bevacizumab (HY-P9906) in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB-c-nu (female, 4-6 weeks old)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; every two days; 21 days
Result:

Significantly suppressed subcutaneous tumor growth compared with vehicle control and bevacizumab.
Reduced final tumor weight and lower tumor vascular density (measured via MRI F-value).

Animal Model:

BALB-c-nu (female, 4-6 weeks old)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; every two days; 3 weeks
Result:

Significantly suppressed intracranial tumor growth (measured via bioluminescence photo flux) compared with vehicle control and bevacizumab.
Reduced intracranial tumor vascular density (measured by CD31-positive vessel count per field) more effectively than bevacizumab.

Gene ID

4162 [NCBI]

Accession

P43121

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa

Aplicación

ELISA, FACS, Functional assay

Chemical Information

SMILES

[Imaprelimab (powder)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Liu W, et al. CD146⁺ pericyte-like lung cancer brain metastatic stem cells promote tumor angiogenesis through dual regulatory effects on the VEGF/VEGFR axis. Theranostics. 2026;16(4):1905-1924. Published 2026 Jan 1. [Content Brief]

[2]. Pelletier J P R, et al. Passive monoclonal and polyclonal antibody therapies[M]//Immunologic concepts in transfusion medicine. Elsevier, 2020: 251-348.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Actividad biológica
- Descripciòn
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

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Referencia número:
Cantidad:
MCE Japan Authorized Agent:

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Imaprelimab (powder)

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Cell Counting Kit-8