Leucomalachite green
Based on 1 publication(s) in Google Scholar
Leucomalachite green is the major reduced metabolite of malachite green (MG) and has lower cytotoxicity (such as HEp-2 and Caco-2) than malachite green. Leucomalachite green may be involved in interfering with cell metabolism or redox balance and can be used to evaluate its potential harm to human cells as a food contaminant.
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- Pureza: 98.72%
- No. CAS: 129-73-7
- Fòrmula: C23H26N2
- Peso molecular:330.47
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Leucomalachite green
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Actividad biológica
Leucomalachite green (30-610 μM; 24 h) does not significantly inhibit cell viability (neutral red uptake assay, total protein content assay) and proliferation ability (colony formation assay) in HEp-2 human laryngeal cancer cell line, showing low cytotoxicity[2].
Leucomalachite green (25-100 μM; 24 h) does not show significant cytotoxicity in Caco-2 human colon cancer cell line experiments, as detected by MTT assay, LDH leakage assay and neutral red uptake assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 129-73-7
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Appearance Solid
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Peso molecular 330.47
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Fòrmula C23H26N2
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Color White to off-white
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SMILES
CN(C)C1=CC=C(C(C2=CC=C(N(C)C)C=C2)C3=CC=CC=C3)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Identification of SARS-CoV-2 Main Protease Inhibitors Using Chemical Similarity Analysis Combined with Machine Learning. [Abstract]2024 Feb 12;17(2):240. PMID: 38399455
Solvente y solubilidad
DMSO : 100 mg/mL (302.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Portuguese - PT (418 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Ya-hui Li, et al. Development of a group selective molecularly imprinted polymers based solid phase extraction of malachite green from fish water and fish feed samples. Anal Chim Acta. 2008 Aug 29;624(2):317-25. [Content Brief]
[2]. Stammati A, et al. Effects of malachite green (MG) and its major metabolite, leucomalachite green (LMG), in two human cell lines. Toxicol In Vitro. 2005 Oct;19(7):853-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0260 mL | 15.1300 mL | 30.2599 mL | 75.6498 mL |
| 5 mM | 0.6052 mL | 3.0260 mL | 6.0520 mL | 15.1300 mL | |
| 10 mM | 0.3026 mL | 1.5130 mL | 3.0260 mL | 7.5650 mL | |
| 15 mM | 0.2017 mL | 1.0087 mL | 2.0173 mL | 5.0433 mL | |
| 20 mM | 0.1513 mL | 0.7565 mL | 1.5130 mL | 3.7825 mL | |
| 25 mM | 0.1210 mL | 0.6052 mL | 1.2104 mL | 3.0260 mL | |
| 30 mM | 0.1009 mL | 0.5043 mL | 1.0087 mL | 2.5217 mL | |
| 40 mM | 0.0756 mL | 0.3782 mL | 0.7565 mL | 1.8912 mL | |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6052 mL | 1.5130 mL | |
| 60 mM | 0.0504 mL | 0.2522 mL | 0.5043 mL | 1.2608 mL | |
| 80 mM | 0.0378 mL | 0.1891 mL | 0.3782 mL | 0.9456 mL | |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.7565 mL |
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