MPO-IN-5
Based on 1 publication(s) in Google Scholar
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1.
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- No. CAS: 2476764-11-9
- Fòrmula: C24H24N6O2
- Peso molecular:428.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]
Chemical Information
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No. CAS 2476764-11-9
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Peso molecular 428.49
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Fòrmula C24H24N6O2
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SMILES
NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Histol Histopathol
MPO-Mediated oxidative stress regulates lung tissue damage in T-COPD through activation of the NLRP3 inflammasome. [Abstract]2025 Oct 20:25006. PMID: 41111480
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPO-IN-5 Related Classifications
HY-147691 Related Classifications
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