2476764-11-9
Chemical Structure
MPO-IN-5
- CAS No.: 2476764-11-9
- Formula:C24H24N6O2
- Molecular Weight:428.49
IUPAC Name: 2-((2-(4-(4-amino-5-(1H-indol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenoxy)ethyl)amino)ethan-1-ol
InChIKey: SQCHQUSSWKGEMI-UHFFFAOYSA-N
SMILES: NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
Biological Activity: MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
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MPO-IN-5 | MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1. | |||||||||||||||||||||
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Keywords
