MPO-IN-5
Based on 1 publication(s) in Google Scholar
MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2476764-11-9
- 分子式: C24H24N6O2
- 分子量:428.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 MPO-IN-5
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生物活性
製品説明
IC50 & Target
IC50: 0.22 μM (MPO peroxidation), 2.8 μM (hERG binding), 30 μM (TPO)[1]
化学情報
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CAS 番号 2476764-11-9
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分子量 428.49
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分子式 C24H24N6O2
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SMILES
NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Histol Histopathol
MPO-Mediated oxidative stress regulates lung tissue damage in T-COPD through activation of the NLRP3 inflammasome. [Abstract]2025 Oct 20:25006. PMID: 41111480
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MPO-IN-5 関連分類
HY-147691 関連分類
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