SRA-36
SRA-36 is a CLC-K chloride channel inhibitor with selectivity over CLC-5 and CLC-1 chloride channels. SRA-36 blocks CLC-Ka currents with an IC50 of 6.6 μM and a Kd of 3.8 μM. SRA-36 blocks chloride currents mediated by targeted channels, and inhibits currents from hypertension-associated CLC-KaA447T and CLC-KaY315F polymorphisms. SRA-36 can be used for the research of hypertension.
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- Fòrmula: C22H16O3
- Peso molecular:328.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
SRA-36 potently inhibits chloride currents from wild-type CLC-Ka channels heterologously expressed in HEK293 cells, with an IC50 of 6.6 μM[1].
SRA-36 potently inhibits chloride currents from wild-type CLC-Ka channels heterologously expressed in MDCK cells, with an apparent KD of 3.8 μM[1].
SRA-36 potently inhibits chloride currents from CLC-Kb and rat CLC-K1 channels heterologously expressed in HEK293 cells, reducing currents by ~90% at 50 μM[1].
SRA-36 (5 μM) does not inhibit chloride currents from CLC-5 or CLC-1 channels heterologously expressed in HEK293 cells at a concentration of 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 328.36
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Fòrmula C22H16O3
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SMILES
OC(C1=C(C2=CC(CC3=CC=CC=C3)=CC=C2O1)C4=CC=CC=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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