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Referencia número: HY-P99518

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Taldefgrobep alfa

(Synonyms: BMS 986089; RG 6206; RO 7239361; BHV2000)

Revisión del cliente

Based on 1 Customer Validation

Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a protein that blocks myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.65%
No. CAS: 1580555-26-5
Peso molecular:75.59 kDa

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Taldefgrobep alfa Chemical Structure

No. CAS: 1580555-26-5

Tamaño

Precio

Stock

Cantidad

Sample (0.1mg)

In-stock

(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Bioz

Actividad biológica

Descripciòn

Species Reactivity

Human

IC₅₀ & Target

Myostatin^[1]

Ver todos los productos específicos de isoformas TGF-beta/Smad :

Smad1
Smad3

In Vivo

Taldefgrobep alfa (2 mg/kg; iv or sc; single dose) has rapid plasma clearance after intravenous administration in mice, but slow absorption (T_max=24 h) after subcutaneous administration with C_max=15.4 mg/mL and bioavailability (F)=84%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

2660 [NCBI]

Accession

O14793

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IGHG1 Fc (Fragment constant)-[peptidyl linker-Alternative to antigen receptors (domain scaffold: FN1 F10, fibronectin domain F10)]2

Chemical Information

No. CAS 1580555-26-5
Appearance Liquid
Peso molecular 75.59 kDa
Color Colorless to light yellow
SMILES

[Taldefgrobep alfa]
Synonyms

BMS 986089; RG 6206; RO 7239361; BHV2000
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (257 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Zhu Y, et al. LC-MS/MS multiplexed assay for the quantitation of a therapeutic protein BMS-986089 and the target protein Myostatin. Bioanalysis. 2016 Feb;8(3):193-204. [Content Brief]

[2]. Straus M. 2023 Pipeline Report: Testing the Limits[J]. Pharmaceutical Executive, 2022, 42(12).

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Actividad biológica
- Descripciòn
- Species Reactivity
- IC50 & Target
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Taldefgrobep alfa

Antibody Inhibitor Library

Ver todos los productos específicos de isoformas TGF-beta/Smad