Thionisoxetine
Thionisoxetine is a norepinephrine transporter inhibitor with a Ki value of 0.2 nM in rats, and exhibits anti-hyperalgesic and analgesic activities. Thionisoxetine reverses thermal hyperalgesia and mechanical allodynia in rats. Thionisoxetine can be used in studies related to persistent inflammatory pain.
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- No. CAS: 155273-01-1
- Fòrmula: C17H21NOS
- Peso molecular:287.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 70-90 g, inflammatory pain model induced by s.c. λ-carrageenan injection)[1]
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Dosage:0.03, 0.1, 0.3, 1, 3, 10 mg/kg; 0.01, 0.03, 0.1, 0.3, 1, 3, 10 mg/kg (co-administered with 10 mg/kg fluoxetine i.p.)
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Administration:i.p.; single dose
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Result:Produced a complete, dose-dependent reversal of carrageenan-induced thermal hyperalgesia, significant at doses of 0.3, 1, 3, and 10 mg/kg.
Produced a greater than 80% reversal of carrageenan-induced mechanical allodynia, significant at doses of 3 and 10 mg/kg.
Produced a significant leftward shift in relative potency for reversing carrageenan-induced thermal hyperalgesia.
Produced a significant leftward shift in relative potency for reversing carrageenan-induced mechanical allodynia.
Increased brain concentrations of thionisoxetine 1.09- to 5.1-fold, with analgesic potentiation exceeding pharmacokinetic changes alone, confirming pharmacodynamic synergism.
Chemical Information
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No. CAS 155273-01-1
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Peso molecular 287.42
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Fòrmula C17H21NOS
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SMILES
O(C=1C=CC=CC1SC)C(C=2C=CC=CC2)CCNC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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