country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

GNB5 - G protein subunit beta 5 Gene

Also Known as GB5; HG2E; IDDCA; LADCI; gbeta5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10681

About GNB5

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,115,100-52,191,392 (from NCBI)

This gene has 12 transcripts (splice variants), 283 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in ovary (RPKM 9.7), kidney (RPKM 8.8) and 25 other tissues.

Summary

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

GNB5 Products (3)

mRNA	Protein	Name
NM_001379343.1	NP_001366272.1	guanine nucleotide-binding protein subunit beta-5 isoform c
NM_006578.4	NP_006569.1	guanine nucleotide-binding protein subunit beta-5 isoform a
NM_016194.4	NP_057278.2	guanine nucleotide-binding protein subunit beta-5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein gamma-subunit binding	IPI IPI: Inferred from physical interaction	12606627	GOA
contributes to GTPase activator activity	IDA IDA: Inferred from direct assay	27677260	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10521509	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12606627	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	19376773	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	27677260	GOA
involved in negative regulation of voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	11007869	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	10521509	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	10521509	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNB5 Protein Structure

WD40

0
100
200
300
395 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein subunit beta-5	G protein, beta subunit 5L

GNB5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GNB5	O14775	PFDN5	Homo sapiens	Q99471	Lumier	25036637
Intra	GNB5	O14775	PFDN5	Homo sapiens	Q99471	Anti Tag CoIP	33961781
Intra	GNB5	O14775	RGS6	Homo sapiens	P49758	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Cardiac Arrhythmia	Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome IDDCA Intellectual Developmental Disorder, With Cardiac Arrhythmia
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia	LADCI Language Delay And Adhd/Cognitive Impairment With Or Without Cardiac Arrhythmia Language Delay, Adhd/Cognitive Impairment With/Without Cardiac Arrhythmia
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Prolonged Electroretinal Response Suppression	Bradyopsia PERRS
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Night Blindness, Congenital Stationary, Type 1h	Congenital Stationary Night Blindness 1h CSNB1H Congenital Stationary Night Blindness Type 1h Night Blindness, Congenital Stationary, 1h
Progressive Familial Heart Block, Type Ib	Progressive Familial Heart Block Type Ib PFHB1B Pfhbib Progressive Familial Heart Block Type 1b Heart Block Progressive Familial Type 1b Progressive Familial Heart Block 1b Cardiac Conduction Block Right-Bundle Branch Block Heart Block, Familial, Progressive, Type 1b Heart Block Right Bundle Branch Block
Congenital Stationary Night Blindness	Night Blindness, Congenital Stationary Congenital Essential Nyctalopia Oguchi Disease Blindness, Night, Stationary, Congenital
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05550	GNB5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22190	Gnb5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28712	Gnb5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GNB5	VGNC	VGNC:80963
Rattus norvegicus	GNB5	RGD	RGD:620759
Mus musculus	GNB5	MGD	MGI:101848
Canis familiaris	GNB5	VGNC	VGNC:41316
Macaca mulatta	GNB5	VGNC	VGNC:73097
Bos taurus	GNB5	VGNC	VGNC:29462
Others	GNB5	NCBI