Wnt7a - Wnt family member 7A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114850

Summary

Enables Frizzled binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of JNK cascade; and response to estradiol. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in Schaffer collateral - CA1 synapse; extracellular space; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt7a Products (1)

mRNA Protein Name
NM_001100473.1 NP_001093943.1 protein Wnt-7a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IPI
IPI: Inferred from physical interaction
18567805 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18567805 RGD
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18567805 RGD
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
18567805 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18567805 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16551644 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-7a

  • wingless-related MMTV integration site 7A

  • wingless-type MMTV integration site 7A

  • wingless-type MMTV integration site family, member 7A

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-105634A Nomegestrol acetate Agonist 99.73% Yes

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D1474 WNT7A-IN-1 sodium Inhibitor 98.05% Unkown
HY-170411 WNT7A-IN-1 Inhibitor 99.66% Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 / Unkown
HY-RS15840 WNT7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt7a NCBI NCBI:7476