MPZL3 - myelin protein zero like 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196264

About MPZL3

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,226,690-118,252,365 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 6 paralogues. Broad expression in skin (RPKM 9.4), esophagus (RPKM 9.0) and 19 other tissues.

Summary

Predicted to be involved in cell adhesion. Predicted to act upstream of or within extracellular matrix organization and hair cycle. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MPZL3 Products (2)

mRNA Protein Name
NM_001286152.2 NP_001273081.1 myelin protein zero-like protein 3 isoform b precursor
NM_198275.3 NP_938016.1 myelin protein zero-like protein 3 isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPZL3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (38 - 147)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

myelin protein zero-like protein 3

MPZL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MPZL3 Q6UWV2 MPZL2 Homo sapiens O60487
SPR
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MPZL3 Proteins

Cat. No. Product Name Accession Purity
HY-P73804 MPZL3 Protein, Human (HEK293, His) Q6UWV2-1 (L32-S158) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Seborrheic Dermatitis

  • Seborrhoeic Dermatitis

  • Seborrhea

  • Seborrhoeic Eczema

  • Skin Seborrheic

  • Dermatitis, Seborrheic
Linear Skin Defects With Multiple Congenital Anomalies 2

  • LSDMCA2

  • Aplasia Cutis Congenita, Reticulolinear, With Microcephaly, Facial Dysmorphism, And Other Congenital Anomalies

  • Aplcc

  • Aplasia Cutis Congenita, Reticulolinear, With Microcephaly, Facial Dysmorphism And Other Congenital Anomalies
Seborrheic Infantile Dermatitis

  • Cradle Cap

  • Infantile Seborrhoeic Dermatitis

  • Seborrhoea Capitis

  • Seborrhoeic Dermatitis Of Scalp

  • Seborrhoeic Eczema Of Scalp

  • Complement 5 Dysfunction

  • Generalized Seborrheic Dermatitis Of Infants

  • Infantile Seborrheic Dermatitis

  • Pityriasis Capitis

  • Seborrhea Capitis

  • Seborrhea Sicca

  • Dandruff

  • Complement Component 5 Deficiency

  • Seborrheic Dermatitis

  • Seborrheic Dermatitis Of Scalp

  • Scurfiness Of Scalp

  • Seborrheic Dermatitis Of Infancy

  • Infantile Seborrhoeic Eczema

  • Neonatal Seborrhoeic Dermatitis

  • Infantile Seborrhoeic Dermatitis Of The Scalp
Axenfeld-Rieger Syndrome, Type 1

  • Axenfeld-Rieger Syndrome Type 1

  • RIEG1

  • Rieg

  • Rgs

  • Rieger Syndrome Type 1

  • Rieger Syndrome, Type 1

  • Axenfeld-Rieger Syndrome 1

  • Iridogoniodysgenesis With Somatic Anomalies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08636 MPZL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19461 Mpzl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25954 Mpzl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MPZL3 VGNC VGNC:74841
Canis familiaris MPZL3 VGNC VGNC:43356
Bos taurus MPZL3 VGNC VGNC:31594
Mus musculus MPZL3 MGD MGI:2442647
Felis catus MPZL3 VGNC VGNC:82016
Rattus norvegicus MPZL3 RGD RGD:1310980
Others MPZL3 NCBI