KLRC2 - killer cell lectin like receptor C2 Gene

Also Known as NKG2C; CD159c; NKG2-C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3822

About KLRC2

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,430,599-10,436,010 (from NCBI)

This gene has 5 transcripts (splice variants), 460 orthologues and 23 paralogues. Biased expression in brain (RPKM 6.7), spleen (RPKM 3.4) and 9 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

KLRC2 Products (1)

mRNA Protein Name
NM_002260.4 NP_002251.2 NKG2-C type II integral membrane protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class I protein complex binding IPI
IPI: Inferred from physical interaction
18448674 GOA
enables activating MHC class Ib receptor activity IDA
IDA: Inferred from direct assay
9754572 GOA
enables protein antigen binding IDA
IDA: Inferred from direct assay
18448674 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9655483 GOA
Biological Process GO Annotation Evidence References Source
involved in natural killer cell mediated immunity IDA
IDA: Inferred from direct assay
18448674 GOA
involved in positive regulation of natural killer cell degranulation IDA
IDA: Inferred from direct assay
21825173 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9754572 GOA
involved in stimulatory C-type lectin receptor signaling pathway IDA
IDA: Inferred from direct assay
9655483 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9655483 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
18448674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRC2 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (135 - 228)

  • 0
  • 100
  • 200
  • 231 a.a.
Protein Preferred Names Protein Names

NKG2-C type II integral membrane protein

  • CD159 antigen-like family member C

KLRC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLRC2 P26717 KLRD1 Homo sapiens Q13241
BN-PAGE
32575403
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRC2 Proteins

Cat. No. Product Name Accession Purity
HY-P77807 NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26717 (E98-L231)&Q13241-1 (S34-I179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78006 NKG2C/CD159c Protein, Human (HEK293, His-Avi) P26717 (E98-L231) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700799 NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi) P26717 (E98-L231) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700800 NKG2C/CD159c Protein, Human (HEK293, hFc) P26717 (E98-L231) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Human Cytomegalovirus Infection

  • Cytomegalovirus Infection

  • Cytomegalovirus Infections
Nk Cell Deficiency
Ceftazidime Allergy

  • Fortaz Allergy

  • Tazicef Allergy
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07392 KLRC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25316 Klrc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLRC2 MGD MGI:1336162
Rattus norvegicus KLRC2 RGD RGD:2977