AGXT2 - alanine--glyoxylate aminotransferase 2 Gene

Homo sapiens

Also known as AGT2; BAIBA; DAIBAT

Gene ID: 64902 | Gene type: protein coding

About AGXT2

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:34,998,102-35,047,949 (from NCBI)

This gene has 6 transcripts (splice variants), 218 orthologues, 4 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 69.3) and liver (RPKM 24.9).

Summary

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

AGXT2 Products(2)

mRNA	Protein	Name
NM_001306173.2	NP_001293102.1	alanine--glyoxylate aminotransferase 2, mitochondrial isoform b precursor
NM_031900.4	NP_114106.1	alanine--glyoxylate aminotransferase 2, mitochondrial isoform a precursor

AGXT2 Protein Structure

Aminotran_3

0
100
200
300
400
514 a.a.

Protein Preferred Names

Protein Names

alanine--glyoxylate aminotransferase 2, mitochondrial

(R)-3-amino-2-methylpropionate--pyruvate transaminase

Related Diseases

Diseases

Alias

Beta-Aminoisobutyric Aciduria

Beta-Aminoisobutyric Acid, Urinary Excretion Of	BAIBA
Baib Urinary Excretion	Hyper-Beta-Aminoisobutyric Aciduria

Hyperoxaluria, Primary, Type Ii

Primary Hyperoxaluria Type 2	D-Glycerate Dehydrogenase Deficiency
Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency	HP2
Oxalosis Ii	Glyceric Aciduria
L-Glyceric Aciduria	Primary Hyperoxaluria, Type Ii
Oxalosis 2	Hyperoxaluria Primary 2
Hyperoxaluria Primary Type Ii	Ph2
Primary Hyperoxaluria Type Ii

Iminoglycinuria

Iminoglycinuria, Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00474	AGXT2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AGXT2	VGNC	VGNC:97343
Rattus norvegicus	AGXT2	RGD	RGD:621767
Macaca mulatta	AGXT2	VGNC	VGNC:81349
Canis familiaris	AGXT2	VGNC	VGNC:50868
Mus musculus	AGXT2	MGD	MGI:2146052

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