(S)-β-Aminoisobutyric acid hydrochloride
Based on 1 publication(s) in Google Scholar
(S)-β-Aminoisobutyric acid hydrochloride is a cytoprotective agent, which is a non-proteinogenic amino acid enantiomer derived from valine metabolism in skeletal muscle mitochondria. The plasma level of (S)-β-Aminoisobutyric acid hydrochloride increases significantly after acute aerobic exercise (and is not affected by the AGXT2 rs37369 genotype), and it is secreted by mouse extensor digitorum longus and soleus muscles in ex vivo contraction assays. (S)-β-Aminoisobutyric acid hydrochloride specifically protects osteocytes from oxidative stress-induced cell death.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 925704-45-6
- Formula: C4H10ClNO2
- Molecular Weight:139.58
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S)-β-Aminoisobutyric acid hydrochloride
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
(S)-β-Aminoisobutyric acid hydrochloride (S-BAIBA) is one of the two chiral enantiomers of β-Aminoisobutyric acid, and is dominated in human plasma (with a concentration approximately 67 times that of the S-form)[1].
Unlike R-BAIBA, whose levels are significantly regulated by AGXT2 gene polymorphisms, S-BAIBA has an extremely low basal plasma concentration and is independent of the effects of this genotype, exerting unique functions in lipid metabolism.
Both show a slight increase after acute exercise, but existing studies emphasize that S-BAIBA and R-BAIBA must be regarded as independent molecules with distinct metabolic origins and regulatory mechanisms, rather than being analyzed collectively as total BAIBA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 925704-45-6
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Appearance Solid
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Molecular Weight 139.58
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Formula C4H10ClNO2
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Color White to off-white
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SMILES
C[C@H](C(O)=O)CN.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Cardiovasc Med
Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway. [Abstract]2022 Feb 25;9:803510. PMID: 35282369
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (716.44 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.1644 mL | 35.8218 mL | 71.6435 mL | 179.1088 mL |
| 5 mM | 1.4329 mL | 7.1644 mL | 14.3287 mL | 35.8218 mL | |
| 10 mM | 0.7164 mL | 3.5822 mL | 7.1644 mL | 17.9109 mL | |
| 15 mM | 0.4776 mL | 2.3881 mL | 4.7762 mL | 11.9406 mL | |
| 20 mM | 0.3582 mL | 1.7911 mL | 3.5822 mL | 8.9554 mL | |
| 25 mM | 0.2866 mL | 1.4329 mL | 2.8657 mL | 7.1644 mL | |
| 30 mM | 0.2388 mL | 1.1941 mL | 2.3881 mL | 5.9703 mL | |
| 40 mM | 0.1791 mL | 0.8955 mL | 1.7911 mL | 4.4777 mL | |
| 50 mM | 0.1433 mL | 0.7164 mL | 1.4329 mL | 3.5822 mL | |
| 60 mM | 0.1194 mL | 0.5970 mL | 1.1941 mL | 2.9851 mL | |
| 80 mM | 0.0896 mL | 0.4478 mL | 0.8955 mL | 2.2389 mL | |
| 100 mM | 0.0716 mL | 0.3582 mL | 0.7164 mL | 1.7911 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S)-β-Aminoisobutyric acid hydrochloride Related Classifications
HY-W023323 Related Classifications
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Keywords
- (S)-β-Aminoisobutyric acid
- 925704-45-6
- Endogenous Metabolite
- non-proteinogenic amino acid enantiomer
- osteocytes
- mitochondria
- cytoprotective agent
- valine metabolism
- skeletal muscle
- S-methylmalonate semialdehyde
- oxidative stress
- mouse extensor digitorum longus muscles
- mouse soleus muscles
- Inhibitor
- inhibitor
- inhibit