(S)-β-Aminoisobutyric acid hydrochloride

Name: (S)-β-Aminoisobutyric acid hydrochloride
Brand: MedChemExpress
SKU: HY-W023323
Rating: 4.5 (1 reviews)

Cat. No.: HY-W023323 Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
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(S)-β-Aminoisobutyric acid hydrochloride is a cytoprotective agent, which is a non-proteinogenic amino acid enantiomer derived from valine metabolism in skeletal muscle mitochondria. The plasma level of (S)-β-Aminoisobutyric acid hydrochloride increases significantly after acute aerobic exercise (and is not affected by the AGXT2 rs37369 genotype), and it is secreted by mouse extensor digitorum longus and soleus muscles in ex vivo contraction assays. (S)-β-Aminoisobutyric acid hydrochloride specifically protects osteocytes from oxidative stress-induced cell death.

For research use only. We do not sell to patients.

(S)-β-Aminoisobutyric acid hydrochloride Chemical Structure

CAS No. : 925704-45-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-β-Aminoisobutyric acid hydrochloride:

(S)-β-Aminoisobutyric acid In-stock
(S)-β-Aminoisobutyric acid (Standard) Get quote

1 Publications Citing Use of MCE (S)-β-Aminoisobutyric acid hydrochloride

•Front Cardiovasc Med. 2022 Feb 25;9:803510. [Abstract]

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Description

In Vitro

(S)-β-Aminoisobutyric acid hydrochloride (S-BAIBA) is one of the two chiral enantiomers of β-Aminoisobutyric acid, and is dominated in human plasma (with a concentration approximately 67 times that of the S-form)^[1].
Unlike R-BAIBA, whose levels are significantly regulated by AGXT2 gene polymorphisms, S-BAIBA has an extremely low basal plasma concentration and is independent of the effects of this genotype, exerting unique functions in lipid metabolism.
Both show a slight increase after acute exercise, but existing studies emphasize that S-BAIBA and R-BAIBA must be regarded as independent molecules with distinct metabolic origins and regulatory mechanisms, rather than being analyzed collectively as total BAIBA.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

139.58

Formula

C₄H₁₀ClNO₂

CAS No.

925704-45-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C(O)=O)CN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (716.44 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1644 mL	35.8218 mL	71.6435 mL
5 mM	1.4329 mL	7.1644 mL	14.3287 mL
10 mM	0.7164 mL	3.5822 mL	7.1644 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (126 KB) RP-HPLC (181 KB) MS (73 KB)

Handling Instructions (2659 KB)

References

[1]. Stautemas J, et al. Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans. Front Physiol. 2019;10:1240. Published 2019 Sep 25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.1644 mL	35.8218 mL	71.6435 mL	179.1088 mL
	5 mM	1.4329 mL	7.1644 mL	14.3287 mL	35.8218 mL
	10 mM	0.7164 mL	3.5822 mL	7.1644 mL	17.9109 mL
	15 mM	0.4776 mL	2.3881 mL	4.7762 mL	11.9406 mL
	20 mM	0.3582 mL	1.7911 mL	3.5822 mL	8.9554 mL
	25 mM	0.2866 mL	1.4329 mL	2.8657 mL	7.1644 mL
	30 mM	0.2388 mL	1.1941 mL	2.3881 mL	5.9703 mL
	40 mM	0.1791 mL	0.8955 mL	1.7911 mL	4.4777 mL
	50 mM	0.1433 mL	0.7164 mL	1.4329 mL	3.5822 mL
	60 mM	0.1194 mL	0.5970 mL	1.1941 mL	2.9851 mL
	80 mM	0.0896 mL	0.4478 mL	0.8955 mL	2.2389 mL
	100 mM	0.0716 mL	0.3582 mL	0.7164 mL	1.7911 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.