TGM3 - transglutaminase 3 Gene

Homo sapiens

Also known as TGE; UHS2

Gene ID: 7053 | Gene type: protein coding

About TGM3

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,296,001-2,341,079 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues, 8 paralogues and is associated with 2 phenotypes. Restricted expression toward esophagus (RPKM 758.5).

Summary

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]

TGM3 Products(1)

mRNA	Protein	Name
NM_003245.4	NP_003236.3	protein-glutamine gamma-glutamyltransferase E

TGM3 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
693 a.a.

Protein Preferred Names

Protein Names

protein-glutamine gamma-glutamyltransferase E

E polypeptide, protein-glutamine-gamma-glutamyltransferase

Recombinant TGM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77257	Transglutaminase 3/TGM3 Protein, Human (sf9, His)	Q08188 (A2-E693)	≥95%

Related Diseases

Diseases

Alias

Uncombable Hair Syndrome 2

UHS2

Uncombable Hair Syndrome 1

Uncombable Hair Syndrome	Pili Trianguli Et Canaliculi
Uhs	Cheveux Incoiffables
Spun Glass Hair	Unmanageable Hair Syndrome
UHS1	Chevelure En Vadrouille

Dermatitis Herpetiformis

Duhring'S Disease	Duhring-Brocq Disease
Dermatosis Herpetiformis	Brocq-Duhring Disease
Dh	Duhring Brocq Disease
Dh - [Dermatitis Herpetiformis]

Balanitis Xerotica Obliterans

Penile Lichen Sclerosus

Penile Leukoplakia

Balanitis

Netherton Syndrome

NETH	Ns
Netherton Disease	Comel-Netherton Syndrome
Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige	Bamboo Hair Syndrome
Ichthyosis Linearis Circumflexa	Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige
Ilc	Nts
N Syndrome

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans

KFSD

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Loose Anagen Hair Syndrome

Loose Anagen Syndrome

LAHS

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Psoriasis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Chronic Cholangitis

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14460	TGM3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TGM3	VGNC	VGNC:81237
Rattus norvegicus	TGM3	RGD	RGD:1561831
Mus musculus	TGM3	MGD	MGI:98732
Canis familiaris	TGM3	VGNC	VGNC:47317
Bos taurus	TGM3	VGNC	VGNC:35811
Macaca mulatta	TGM3	VGNC	VGNC:98457
Others	TGM3	NCBI