TGM3 - transglutaminase 3 Gene

Also Known as TGE; UHS2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7053

About TGM3

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,296,001-2,341,079 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues, 8 paralogues and is associated with 2 phenotypes. Restricted expression toward esophagus (RPKM 758.5).

Summary

Transglutaminases are Enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]

TGM3 Products (1)

mRNA	Protein	Name
NM_003245.4	NP_003236.3	protein-glutamine gamma-glutamyltransferase E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	12679341	GOA
enables catalytic activity	IDA IDA: Inferred from direct assay	8099584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein-glutamine gamma-glutamyltransferase activity	IDA IDA: Inferred from direct assay	8099584	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	5038456	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in keratinocyte differentiation	IEP IEP: Inferred from expression pattern	12850301	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	24643	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12850301	GOA
located in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	5038456	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	5038456	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGM3 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
693 a.a.

Protein Preferred Names	Protein Names
protein-glutamine gamma-glutamyltransferase E	E polypeptide, protein-glutamine-gamma-glutamyltransferase

TGM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TGM3	Q08188	PPME1	Homo sapiens	Q9Y570	Anti Tag CoIP	33961781
Intra	TGM3	Q08188	PPME1	Homo sapiens	Q9Y570	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TGM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77257	Transglutaminase 3/TGM3 Protein, Human (sf9, His)	Q08188 (A2-E693)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Uncombable Hair Syndrome 2	UHS2
Uncombable Hair Syndrome 1	Uncombable Hair Syndrome Pili Trianguli Et Canaliculi Uhs Cheveux Incoiffables Spun Glass Hair Unmanageable Hair Syndrome UHS1 Chevelure En Vadrouille
Dermatitis Herpetiformis	Duhring'S Disease Duhring-Brocq Disease Dermatosis Herpetiformis Brocq-Duhring Disease Dh Duhring Brocq Disease Dh - [Dermatitis Herpetiformis]
Balanitis Xerotica Obliterans	Penile Lichen Sclerosus Penile Leukoplakia
Balanitis
Netherton Syndrome	NETH Ns Netherton Disease Comel-Netherton Syndrome Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige Bamboo Hair Syndrome Ichthyosis Linearis Circumflexa Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige Ilc Nts N Syndrome
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant	Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans KFSD
Peeling Skin Syndrome	Deciduous Skin Familial Continuous Skin Peeling Syndrome Idiopathic Deciduous Skin Keratosis Exfoliativa Congenita Pss Peeling Skin Disease Skin Peeling Syndrome Familial Continuous Skin Peeling Keratolysis Exfoliativa Congenita Exfoliation Syndrome Keratolysis Exfoliativa
Loose Anagen Hair Syndrome	Loose Anagen Syndrome LAHS
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Psoriasis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Chronic Cholangitis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14460	TGM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21442	Tgm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27960	Tgm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TGM3	VGNC	VGNC:81237
Rattus norvegicus	TGM3	RGD	RGD:1561831
Mus musculus	TGM3	MGD	MGI:98732
Canis familiaris	TGM3	VGNC	VGNC:47317
Bos taurus	TGM3	VGNC	VGNC:35811
Macaca mulatta	TGM3	VGNC	VGNC:98457
Others	TGM3	NCBI