FCN3 - ficolin 3 Gene

Also Known as FCNH; HAKA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8547

About FCN3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,369,110-27,374,824 (from NCBI)

This gene has 6 transcripts (splice variants), 52 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in lung (RPKM 93.2), liver (RPKM 47.7) and 3 other tissues.

Summary

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

FCN3 Products (2)

mRNA	Protein	Name
NM_003665.4	NP_003656.2	ficolin-3 isoform 1 precursor
NM_173452.3	NP_775628.1	ficolin-3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables antigen binding	IDA IDA: Inferred from direct assay	22851708	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19109177	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11907111	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in complement activation	IDA IDA: Inferred from direct assay	22851708	GOA
involved in complement activation, lectin pathway	IDA IDA: Inferred from direct assay	11907111	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	22851708	GOA
involved in negative regulation of RNA biosynthetic process	IDA IDA: Inferred from direct assay	22851708	GOA
involved in negative regulation of viral entry into host cell	IMP IMP: Inferred from mutant phenotype	22851708	GOA
involved in positive regulation of opsonization	IDA IDA: Inferred from direct assay	11907111	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	11907111	GOA
involved in recognition of apoptotic cell	IDA IDA: Inferred from direct assay	15804047	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of serine-type endopeptidase complex	IDA IDA: Inferred from direct assay	11907111	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCN3 Protein Structure

Collagen

Fibrinogen_C

0
100
200
299 a.a.

Protein Preferred Names	Protein Names
ficolin-3	H-ficolin

FCN3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FCN3	O75636	MASP1	Homo sapiens	P48740-2	GMS	23785123
Intra	FCN3	O75636	MASP1	Homo sapiens	P48740-3	GMS	23785123
Intra	FCN3	O75636	FCN2	Homo sapiens	Q15485	Anti Bait CoIP	32094208
Cross	FCN3	O75636	fbpB	Mycobacterium tuberculosis	P9WQP1	Anti Bait CoIP	27141819

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ficolin 3 Deficiency	Immunodeficiency Due To Ficolin 3 Deficiency Immunodeficiency Due To Ficolin3 Deficiency Fcn3 Deficiency Lcapd3 Lectin Complement Activation Pathway, Defect In, 3 FCN3D Defect In Lectin Complement Activation Pathway, 3
Rheumatic Heart Disease	Rheumatic Carditis Rheumatic Congestive Heart Failure Congestive Rheumatic Heart Failure Rheumatic Heart Failure RHD Rheumatic Fever Inactive Or Quiescent With Heart Disease Rheumatic Fever Inactive Or Quiescent With Carditis Organ Rheumatic Heart Disease Organic Rheumatic Heart Disease Inactive Rheumatic Heart Disease Rheumatic Heart Rheumatic Fever Inactive Or Quiescent With Pancarditis Rhd - [Rheumatic Heart Disease] Rheumatic Cardiac Hypertrophy Rheumatic Fever Inactive Or Quiescent With Cardiac Hypertrophy Rheumatic Pancarditis Inactive Rhd - [Rheumatic Heart Disease] Rheumatic Nonischaemic Cardiopathy
Rheumatic Fever	Acute Rheumatic Fever Rhf - Rheumatic Fever Inflammatory Rheumatism Active Rheumatic Fever Nos Acute Active Rheumatic Fever Subacute Active Rheumatic Fever Subacute Rheumatic Fever Active Rheumatic Fever With Unspecified Type Of Heart Involvement Acute Rheumatic Heart Disease Active Rheumatic Heart Disease Acute Organic Rhd - [Rheumatic Heart Disease] Acute Rhd - [Rheumatic Heart Disease]
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
3mc Syndrome	Craniofacial-Ulnar-Renal Syndrome Malpuech Facial Clefting Syndrome Oculopalatoskeletal Syndrome Carnevale Syndrome Michels Syndrome Malpuech-Michels-Mingarelli-Carnevale Syndrome Carnevale-Krajewska-Fischetto Syndrome Craniosynostosis With Lid Anomalies Malpuech Syndrome Mingarelli Syndrome Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Ptosis-Strabismus-Rectus Abdominis Diastasis
3mc Syndrome 2	3MC2 Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Carnevale Syndrome Carnevale Syndrome, Formerly Carnevale Krajewska Fischetto Syndrome 3mc Syndrome, Type 2
3mc Syndrome 1	Oculopalatoskeletal Syndrome 3MC1 Craniosynostosis With Lid Anomalies Michels Syndrome, Formerly Michels Syndrome 3mc Syndrome, Type 1
Pulmonary Aspergilloma
Agammaglobulinemia 4, Autosomal Recessive	Agammaglobulinemia 4 AGM4 Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect B Cell Linker Protein Deficiency B-Cell Linker Protein Deficiency Blnk Deficiency Agammaglobulinemia Autosomal Recessive Due To Blnk Defect Agammaglobulinemia, Type 4, Autosomal Recessive
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04841	FCN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FCN3	VGNC	VGNC:72630
Rattus norvegicus	FCN3	RGD	RGD:621221
Others	FCN3	NCBI