SNAPC5 - small nuclear RNA activating complex polypeptide 5 Gene

Also Known as SNAP19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10302

About SNAPC5

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,489,748-66,497,762 (from NCBI)

This gene has 8 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in brain (RPKM 30.5), fat (RPKM 21.0) and 25 other tissues.

Summary

This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits Other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

SNAPC5 Products (4)

mRNA	Protein	Name
NM_001329613.2	NP_001316542.1	snRNA-activating protein complex subunit 5 isoform 2
NM_001329614.2	NP_001316543.1	snRNA-activating protein complex subunit 5 isoform 3
NM_001329615.2	NP_001316544.1	snRNA-activating protein complex subunit 5 isoform 1
NM_006049.4	NP_006040.1	snRNA-activating protein complex subunit 5 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	9732265	GOA
enables RNA polymerase III general transcription initiation factor activity	IDA IDA: Inferred from direct assay	9732265	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11056176	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in snRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9732265	GOA
involved in snRNA transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	9732265	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNAPC5 Protein Structure

SNAPc19

0
98 a.a.

Protein Preferred Names	Protein Names
snRNA-activating protein complex subunit 5	SNAPc 19 kDa subunit

SNAPC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNAPC5	O75971	DDIT3	Homo sapiens	P35638-2	Validated Y2H	25416956
Intra	SNAPC5	O75971	NOL4	Homo sapiens	O94818-2	Validated Y2H	25416956
Intra	SNAPC5	O75971	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	25416956
Intra	SNAPC5	O75971	NMI	Homo sapiens	Q13287	Validated Y2H	25416956
Intra	SNAPC5	O75971	NMI	Homo sapiens	Q13287	Y2H Array	25416956
Intra	SNAPC5	O75971	NMI	Homo sapiens	Q13287	Y2H	21516116
Intra	SNAPC5	O75971	NMI	Homo sapiens	Q13287	Y2H Prey Pooling	25416956
Intra	SNAPC5	O75971	AMOT	Homo sapiens	Q4VCS5-2	Y2H Prey Pooling	25416956
Intra	SNAPC5	O75971	NUDT10	Homo sapiens	Q8NFP7	Validated Y2H	25416956
Intra	SNAPC5	O75971	NUDT10	Homo sapiens	Q8NFP7	Y2H Array	25416956
Intra	SNAPC5	O75971	ZNRD2	Homo sapiens	O60232	Y2H Array	25416956
Intra	SNAPC5	O75971	ZNRD2	Homo sapiens	O60232	Validated Y2H	25416956
Intra	SNAPC5	O75971	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	25416956
Intra	SNAPC5	O75971	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

SNAPC5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810109	SNAPC 19 Antibody (YA9453)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13480	SNAPC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNAPC5	VGNC	VGNC:35057
Rattus norvegicus	SNAPC5	RGD	RGD:1582813
Felis catus	SNAPC5	VGNC	VGNC:65523
Macaca mulatta	SNAPC5	VGNC	VGNC:77712
Mus musculus	SNAPC5	MGD	MGI:1914282
Canis familiaris	SNAPC5	VGNC	VGNC:46594
Others	SNAPC5	NCBI