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RPL4 - ribosomal protein L4 Gene

Also Known as L4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6124

About RPL4

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,498,015-66,504,855 (from NCBI)

This gene has 17 transcripts (splice variants) and 229 orthologues. Ubiquitous expression in ovary (RPKM 1453.8), lymph node (RPKM 857.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL4 Products (1)

mRNA	Protein	Name
NM_000968.4	NP_000959.2	60S ribosomal protein L4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	24454821	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL4 Protein Structure

Ribosomal_L4

Ribos_L4_asso_C

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L4	60S ribosomal protein L1

RPL4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPL4	P36578	RPL18A	Homo sapiens	Q02543	Crosslink	30021884
Intra	RPL4	P36578	RPL18	Homo sapiens	Q07020	Anti Tag CoIP	35271311
Intra	RPL4	P36578	RPL18	Homo sapiens	Q07020	Crosslink	30021884
Intra	RPL4	P36578	RPS20	Homo sapiens	P60866	Anti Bait CoIP	25866880
Intra	RPL4	P36578	RPS20	Homo sapiens	P60866	Anti Tag CoIP	35271311
Intra	RPL4	P36578	RPL14	Homo sapiens	P50914	Anti Tag CoIP	35271311
Intra	RPL4	P36578	RPL14	Homo sapiens	P50914	Crosslink	30021884
Intra	RPL4	P36578	MAP3K14	Homo sapiens	Q99558	TAP	14743216
Intra	RPL4	P36578	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	RPL4	P36578	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	RPL4	P36578	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	RPL4	P36578	HTT	Homo sapiens	P42858	Lumier	23275563

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Babesiosis	Babesiasis Infection By Babesia Piroplasmosis Human Babesiosis Babesia Parasite Infection Piroplasma Infection
Retinitis Pigmentosa 25	RP25 Retinitis Pigmentosa-25 Retinitis Pigmentosa, Type 25
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12199	RPL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17895	Rpl4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24364	Rpl4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL4	RGD	RGD:619824
Macaca mulatta	RPL4	VGNC	VGNC:99232
Mus musculus	RPL4	MGD	MGI:1915141
Felis catus	RPL4	VGNC	VGNC:80870
Others	RPL4	NCBI