RPL18 - ribosomal protein L18 Gene

Also Known as L18; DBA18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6141

About RPL18

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,615,331-48,619,178 (from NCBI)

This gene has 16 transcripts (splice variants), 176 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 914.0), lymph node (RPKM 396.5) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RPL18 Products (2)

mRNA Protein Name
NM_000979.4 NP_000970.1 60S ribosomal protein L18 isoform 1
NM_001270490.2 NP_001257419.1 60S ribosomal protein L18 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30021884 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoplasmic translation IDA
IDA: Inferred from direct assay
25957688 GOA
Cellular Component GO Annotation Evidence References Source
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
25957688 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL18 Protein Structure

Ribosomal_L27A

Ribosomal_L27A: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A (4 - 123)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L18

  • large ribosomal subunit protein eL18

RPL18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPL18 Q07020 RPL4 Homo sapiens P36578
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia 18

  • DBA18

  • Rpl18-Related Diamond-Blackfan Anemia
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Barber-Say Syndrome

  • Hypertrichosis, Atrophic Skin, Ectropion, And Macrostomia

  • Barber Say Syndrome

  • BBRSAY

  • Bss

  • Hypertrichosis Atrophic Skin Ectropion Macrostomia

  • Hypertrichosis-Atrophic Skin-Ectropion-Macrostomia Syndrome
Macrocytic Anemia

  • Anemia Macrocytic

  • Anemia, Macrocytic

  • Macrocytic Anaemia
Pierre Robin Syndrome

  • Pierre Robin Sequence

  • Glossoptosis, Micrognathia, And Cleft Palate

  • Pierre Robin Syndrome Skeletal Dysplasia Polydactyly

  • Pierre-Robin Syndrome

  • Isolated Pierre Robin Sequence

  • Isolated Pierre-Robin Syndrome

  • PRBNS

  • Robin Sequence

  • Robin Syndrome

  • Isolated Pierre Robin Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12169 RPL18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12170 RPL18A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22782 Rpl18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29296 Rpl18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RPL18 VGNC VGNC:45714
Mus musculus RPL18 MGD MGI:98003
Rattus norvegicus RPL18 RGD RGD:621182
Bos taurus RPL18 VGNC VGNC:34111
Others RPL18 NCBI