RES-701-1
RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ETB receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET)-1) to the ETB receptor, with an IC50 value of 10 nM.
For research use only. We do not sell to patients.
- CAS No.: 151308-34-8
- Formula: C103H115N23O23
- Molecular Weight:2043.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ETB 10 nM (IC50) |
Chemical Information
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CAS No. 151308-34-8
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Molecular Weight 2043.16
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Formula C103H115N23O23
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Sequence
Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp (Lactam bridge:Gly1-Asp9)
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Sequence Shortening
GNWHGTAPDWFFNYYW (Lactam bridge: Gly1-Asp9)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tanaka T, et al. RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin. Mol Pharmacol. 1994 Apr;45(4):724-30. [Content Brief]
[2]. Yamasaki M, et al. RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701 II. Determination of the primary sequence[J]. The Journal of Antibiotics, 1994, 47(3): 276-280. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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