Dasotraline hydrochloride
Based on 1 Customer Validation
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 675126-08-6
- Formula: C16H16Cl3N
- Molecular Weight:328.66
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 4 nM (dopamine), 6 nM (norepinephrine), 11 nM (serotonin)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 675126-08-6
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Appearance Solid
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Molecular Weight 328.66
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Formula C16H16Cl3N
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Color White to off-white
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SMILES
N[C@@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C31.Cl[H]
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Synonyms
SEP-225289 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 31 mg/mL (94.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1.61 mg/mL (4.90 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Guiard BP, et al. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol. 2011 Mar;14(2):211-23. [Content Brief]
[2]. DeLorenzo C, et al. SEP-225289 serotonin and dopamine transporter occupancy: a PET study. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.0427 mL | 15.2133 mL | 30.4266 mL | 76.0665 mL |
| DMSO | 5 mM | 0.6085 mL | 3.0427 mL | 6.0853 mL | 15.2133 mL |
| 10 mM | 0.3043 mL | 1.5213 mL | 3.0427 mL | 7.6066 mL | |
| 15 mM | 0.2028 mL | 1.0142 mL | 2.0284 mL | 5.0711 mL | |
| 20 mM | 0.1521 mL | 0.7607 mL | 1.5213 mL | 3.8033 mL | |
| 25 mM | 0.1217 mL | 0.6085 mL | 1.2171 mL | 3.0427 mL | |
| 30 mM | 0.1014 mL | 0.5071 mL | 1.0142 mL | 2.5355 mL | |
| 40 mM | 0.0761 mL | 0.3803 mL | 0.7607 mL | 1.9017 mL | |
| 50 mM | 0.0609 mL | 0.3043 mL | 0.6085 mL | 1.5213 mL | |
| 60 mM | 0.0507 mL | 0.2536 mL | 0.5071 mL | 1.2678 mL | |
| 80 mM | 0.0380 mL | 0.1902 mL | 0.3803 mL | 0.9508 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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