Serum/glucocorticoid-regulated kinase 1 contributes to the proliferation of varicella-zoster virus and induction of cyclin B1 expression

  • Arch Virol. 2024 May 9;169(5):116. doi: 10.1007/s00705-024-06051-1.
Shinya Oda  1 ,  Akinobu Yokoyama  2 ,  Ryuta Kishii  2 ,  Michiaki Nagasawa  2
Affiliations
  • 1. Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan. [email protected].
  • 2. Watarase Research Center, Kyorin Pharmaceutical Co. Ltd., Shimotsuga-gun, Tochigi, Japan.
PMID: 38722402 DOI: 10.1007/s00705-024-06051-1
Abstract

In this study, we investigated the role of serum/glucocorticoid-regulated kinase 1 (SGK1) in varicella-zoster virus (VZV) replication. VZV DNA replication and plaque formation were inhibited by SGK1 knockout and treatment with an SGK1 Inhibitor. Furthermore, SGK1 inhibition suppressed the increase in cyclin B1 expression induced by VZV Infection. These results suggest that VZV Infection induces SGK1 activation, which is required for efficient viral proliferation through the expression of cyclin B1. This is the first study to report that SGK1 is involved in the VZV life cycle.

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