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GOLGA4 - golgin A4 Gene

Also Known as GCP2; GOLG; p230; CRPF46; MU-RMS-40.18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2803

About GOLGA4

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:37,243,271-37,366,879 (from NCBI)

This gene has 14 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in thyroid (RPKM 27.2), testis (RPKM 25.9) and 25 other tissues.

Summary

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during Mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GOLGA4 Products (3)

mRNA	Protein	Name
NM_001172713.2	NP_001166184.1	golgin subfamily A member 4 isoform 1
NM_001410721.1	NP_001397650.1	golgin subfamily A member 4 isoform 3
NM_002078.5	NP_002069.2	golgin subfamily A member 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	14580338	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15265687	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	15265687	GOA
involved in Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	22705394	GOA
involved in positive regulation of axon extension	IDA IDA: Inferred from direct assay	22705394	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15265687	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15265687	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOLGA4 Protein Structure

GRIP

0
400
800
1200
1600
2000
2230 a.a.

Protein Preferred Names	Protein Names
golgin subfamily A member 4	256 kDa golgin

GOLGA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GOLGA4	Q13439	EXOC1	Homo sapiens	Q9NV70	Y2H	17043677
Intra	GOLGA4	Q13439	LIMD1	Homo sapiens	Q9UGP4	Anti Tag CoIP	33961781
Intra	GOLGA4	Q13439	ANKRD27	Homo sapiens	Q96NW4	Anti Tag CoIP	22705394

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Neutrophilic Leukemia	Cnl Leukemia Neutrophilic Chronic
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Alzheimer Disease 14	AD14 Alzheimer'S Disease 14 Alzheimer Disease-14 Alzheimer'S Disease 14, Late Onset
Glycogen Storage Disease Ixa	Glycogen Storage Disease Type 9a Glycogen Storage Disease Type Ixa Glycogenosis Type 9a Glycogenosis Type Ixa Gsd Type 9a Gsd Type Ixa Gsd9a
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05585	GOLGA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GOLGA4	MGD	MGI:1859646
Bos taurus	GOLGA4	VGNC	VGNC:29485
Rattus norvegicus	GOLGA4	RGD	RGD:1591925
Canis familiaris	GOLGA4	VGNC	VGNC:41340
Felis catus	GOLGA4	VGNC	VGNC:62639
Macaca mulatta	GOLGA4	VGNC	VGNC:73107