LIMD1 - LIM domain containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8994

About LIMD1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,594,751-45,686,341 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 16.2), thyroid (RPKM 9.3) and 25 other tissues.

Summary

Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; regulation of gene expression; and response to hypoxia. Acts upstream of or within P-body assembly and gene silencing by miRNA. Located in several cellular components, including P-body; adherens junction; and focal adhesion. Part of RISC complex. [provided by Alliance of Genome Resources, Apr 2022]

LIMD1 Products (1)

mRNA Protein Name
NM_014240.3 NP_055055.1 LIM domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15542589 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within P-body assembly IMP
IMP: Inferred from mutant phenotype
20616046 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in miRNA-mediated gene silencing by inhibition of translation IMP
IMP: Inferred from mutant phenotype
20616046 GOA
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IMP
IMP: Inferred from mutant phenotype
20616046 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15542589 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22286099 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
20303269 GOA
involved in phosphorylation IDA
IDA: Inferred from direct assay
18439753 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in response to hypoxia IDA
IDA: Inferred from direct assay
22286099 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
20616046 GOA
part of RISC complex IDA
IDA: Inferred from direct assay
20616046 GOA
located in adherens junction IDA
IDA: Inferred from direct assay
20303269 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15542589 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
18439753 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15542589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMD1 Protein Structure

LIM

LIM: LIM domain (472 - 526)

LIM

LIM: LIM domain (537 - 591)

LIM

LIM: LIM domain (597 - 661)

  • 0
  • 200
  • 400
  • 600
  • 676 a.a.
Protein Preferred Names Protein Names

LIM domain-containing protein 1

  • LIM domains containing 1

LIMD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIMD1 Q9UGP4 AGO2 Homo sapiens Q9UKV8
Anti Bait CoIP
28683311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07659 LIMD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22608 Limd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26201 Lmcd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29123 Limd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LIMD1 VGNC VGNC:30888
Macaca mulatta LIMD1 VGNC VGNC:74268
Mus musculus LIMD1 MGD MGI:1352502
Rattus norvegicus LIMD1 RGD RGD:1309830
Canis familiaris LIMD1 VGNC VGNC:42679
Felis catus LIMD1 VGNC VGNC:68052
Others LIMD1 NCBI