SLF2 - SMC5-SMC6 complex localization factor 2 Gene

Also Known as C10orf6; FAM178A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55719

About SLF2

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,912,963-100,965,134 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 1 paralogue. Broad expression in testis (RPKM 12.5), ovary (RPKM 7.5) and 24 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in chromatin; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SLF2 Products (3)

mRNA Protein Name
NM_001136123.2 NP_001129595.1 SMC5-SMC6 complex localization factor protein 2 isoform 2
NM_001243770.2 NP_001230699.1 SMC5-SMC6 complex localization factor protein 2 isoform 3
NM_018121.4 NP_060591.3 SMC5-SMC6 complex localization factor protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25931565 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
25931565 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25931565 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
25931565 GOA
involved in positive regulation of double-strand break repair IDA
IDA: Inferred from direct assay
25931565 GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
25931565 GOA
involved in positive regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
25931565 GOA
involved in protein localization to site of double-strand break IDA
IDA: Inferred from direct assay
25931565 GOA
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
36373674 GOA
located in chromatin IDA
IDA: Inferred from direct assay
24561620 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24561620 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
25931565 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLF2 Protein Structure

FAM178

FAM178: Family of unknown function, FAM178 (652 - 1031)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1173 a.a.
Protein Preferred Names Protein Names

SMC5-SMC6 complex localization factor protein 2

  • family with sequence similarity 178, member A

SLF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLF2 Q8IX21 SLF1 Homo sapiens Q9BQI6
Anti Tag CoIP
36373674
Intra
SLF2 Q8IX21 SLF1 Homo sapiens Q9BQI6
Anti Tag CoIP
26496610
Intra
SLF2 Q8IX21 SLF1 Homo sapiens Q9BQI6
Y2H
32389690
Intra
SLF2 Q8IX21 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
SLF2 Q8IX21 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
SLF2 Q8IX21 SMC5 Homo sapiens Q8IY18
Anti Tag CoIP
33961781
Intra
SLF2 Q8IX21 SMC5 Homo sapiens Q8IY18
Y2H
32389690
Intra
SLF2 Q8IX21 SMC6 Homo sapiens Q96SB8
Anti Tag CoIP
33961781
Intra
SLF2 Q8IX21 SMC6 Homo sapiens Q96SB8
Y2H
32389690
Intra
SLF2 Q8IX21 SIMC1 Homo sapiens Q8NDZ2
Pull Down
36373674
Intra
SLF2 Q8IX21 SIMC1 Homo sapiens Q8NDZ2
Anti Tag CoIP
36373674
Intra
SLF2 Q8IX21 SIMC1 Homo sapiens Q8NDZ2
GMS
36373674
Intra
SLF2 Q8IX21 SIMC1 Homo sapiens Q8NDZ2
Confocal
36373674
Intra
SLF2 Q8IX21 SIMC1 Homo sapiens Q8NDZ2
Anti Tag CoIP
33961781
Intra
SLF2 Q8IX21 SIMC1 Homo sapiens Q8NDZ2
3D-EM
36373674
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Form Agnosia
Alveoli Adenoma

  • Alveolar Adenoma

  • Adenoma Of Alveoli

  • Adenoma Of The Alveoli
Bronchial Benign Neoplasm

  • Bronchus Neoplasm

  • Neoplasm Of Bronchus

  • Bronchial Neoplasms

  • Bronchial Neoplasm
Papillorenal Syndrome

  • Renal Coloboma Syndrome

  • Coloboma Of Optic Nerve With Renal Disease

  • Renal-Coloboma Syndrome

  • Optic Nerve Coloboma With Renal Disease

  • Optic Coloboma, Vesicoureteral Reflux, And Renal Anomalies

  • Renal-Coloboma Syndrome With Macular Abnormalities

  • Congenital Anomalies Of The Kidney And Urinary Tract With Or Without Ocular Abnormalities

  • Cakut With Or Without Ocular Abnormalities

  • PAPRS

  • Optic Coloboma, Vesicoureteral Reflux And Renal Anomalies

  • Papillo-Renal Syndrome, Optic Nerve Coloboma With Renal Disease

  • Coloboma-Ureteral-Renal Syndrome

  • Oncr

  • Optic Nerve Coloboma Renal Syndrome

  • Rcs

  • Papillo-Renal Syndrome

  • Optic Coloboma Vesicoureteral Reflux And Renal Anomalies
Mitochondrial Dna Depletion Syndrome 7

  • Ohaha Syndrome

  • Infantile Onset Spinocerebellar Ataxia

  • Iosca

  • Infantile-Onset Spinocerebellar Ataxia

  • Spinocerebellar Ataxia 8

  • MTDPS7

  • Ophthalmoplegia, Hypotonia, Ataxia, Hypacusis, And Athetosis

  • Ophthalmoplegia-Hypotonia-Ataxia-Hypoacusis-Athetosis Syndrome

  • Sca8

  • Spinocerebellar Ataxia Infantile With Sensory Neuropathy

  • Spinocerebellar Ataxia, Infantile-Onset

  • Ophthalmoplegia, Hypotonia, Ataxia, Hypoacusis, And Athetosis

  • Spinocerebellar Ataxia, Infantile, With Sensory Neuropathy

  • Spinocerebellar Ataxia 8, Formerly

  • Sca8, Formerly

  • Iosca, Mitochondrial Dna Depletion Syndrome 7

  • Ophthalmoplegia - Hypotonia - Ataxia - Hypoacusis - Athetosis

  • Mitochondrial Dna Depletion Syndrome, Hepatocerebrorenal Form

  • Mtdna Depletion Syndrome, Hepatocerebrorenal Form

  • Mitochondrial Dna Depletion Syndrome 7 Hepatocerebral Type

  • Ophthalmoplegia Hypotonia Ataxia Hypoacusis And Athetosis

  • Pure Spinocerebellar Ataxia Japanese Type

  • Sca4 Pure Japanese Type

  • Spinocerebellar Ataxia Infantile-Onset

  • Mitochondrial Dna Depletion Syndrome , Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13362 SLF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLF2 VGNC VGNC:106104
Rattus norvegicus SLF2 RGD RGD:1560300
Mus musculus SLF2 MGD MGI:1924968
Canis familiaris SLF2 VGNC VGNC:53013
Felis catus SLF2 VGNC VGNC:107070
Bos taurus SLF2 VGNC VGNC:34958
Others SLF2 NCBI