SMC6 - structural maintenance of chromosomes 6 Gene

Also Known as SMC-6; hSMC6; SMC6L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79677

About SMC6

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,663,812-17,753,810 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 1 paralogue. Broad expression in testis (RPKM 13.9), lymph node (RPKM 7.0) and 24 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC6 Products (2)

mRNA Protein Name
NM_001142286.2 NP_001135758.1 structural maintenance of chromosomes protein 6
NM_024624.6 NP_078900.1 structural maintenance of chromosomes protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA secondary structure binding IDA
IDA: Inferred from direct assay
28095508 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11408570 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25931565 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
11408570 GOA
involved in cellular senescence IMP
IMP: Inferred from mutant phenotype
17589526 GOA
involved in negative regulation by host of viral genome replication IDA
IDA: Inferred from direct assay
28095508 GOA
involved in positive regulation of chromosome segregation IMP
IMP: Inferred from mutant phenotype
25931565 GOA
involved in telomere maintenance via recombination IMP
IMP: Inferred from mutant phenotype
17589526 GOA
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
17589526 GOA
part of Smc5-Smc6 complex IDA
IDA: Inferred from direct assay
18086888 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
17589526 GOA
located in interchromatin granule IDA
IDA: Inferred from direct assay
11408570 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
28095508 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11408570 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
25931565 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMC6 Protein Structure

SMC_N

SMC_N: RecF/RecN/SMC N terminal domain (48 - 1065)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1091 a.a.
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 6

  • SMC protein 6

SMC6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMC6 Q96SB8 NSMCE3 Homo sapiens Q96MG7
Anti Bait CoIP
18086888
Intra
SMC6 Q96SB8 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
27427983
Intra
SMC6 Q96SB8 NSMCE3 Homo sapiens Q96MG7
Anti Tag CoIP
26496610
Intra
SMC6 Q96SB8 NSMCE1 Homo sapiens Q8WV22
Anti Bait CoIP
18086888
Intra
SMC6 Q96SB8 NSMCE1 Homo sapiens Q8WV22
Anti Tag CoIP
26496610
Intra
SMC6 Q96SB8 NSMCE2 Homo sapiens Q96MF7
Anti Tag CoIP
33961781
Intra
SMC6 Q96SB8 NSMCE2 Homo sapiens Q96MF7
Anti Bait CoIP
18086888
Intra
SMC6 Q96SB8 NSMCE2 Homo sapiens Q96MF7
Anti Tag CoIP
26496610
Intra
SMC6 Q96SB8 SLF2 Homo sapiens Q8IX21
Pull Down
32389690
Intra
SMC6 Q96SB8 SLF2 Homo sapiens Q8IX21
Anti Tag CoIP
32389690
Intra
SMC6 Q96SB8 SLF2 Homo sapiens Q8IX21
Anti Tag CoIP
26496610
Intra
SMC6 Q96SB8 SMC5 Homo sapiens Q8IY18
Anti Tag CoIP
33961781
Intra
SMC6 Q96SB8 SMC5 Homo sapiens Q8IY18
Anti Tag CoIP
26496610
Intra
SMC6 Q96SB8 SMC5 Homo sapiens Q8IY18
Anti Bait CoIP
18086888
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Breast Melanoma

  • Malignant Melanoma Of Breast

  • Breast Melanoma
Fanconi Anemia, Complementation Group F

  • Fanconi Anemia Complementation Group F

  • FANCF
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13422 SMC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184425 HBx-DDB1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SMC6 MGD MGI:1914491
Rattus norvegicus SMC6 RGD RGD:1311214
Bos taurus SMC6 VGNC VGNC:35003
Canis familiaris SMC6 VGNC VGNC:46547
Felis catus SMC6 VGNC VGNC:65480
Macaca mulatta SMC6 VGNC VGNC:77746
Others SMC6 NCBI