SMC6 - structural maintenance of chromosomes 6 Gene

Homo sapiens

Also known as SMC-6; hSMC6; SMC6L1

Gene ID: 79677 | Gene type: protein coding

About SMC6

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,663,812-17,753,810 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 1 paralogue. Broad expression in testis (RPKM 13.9), lymph node (RPKM 7.0) and 24 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC6 Products(2)

mRNA	Protein	Name
NM_001142286.2	NP_001135758.1	structural maintenance of chromosomes protein 6
NM_024624.6	NP_078900.1	structural maintenance of chromosomes protein 6

SMC6 Protein Structure

SMC_N

0
200
400
600
800
1000
1091 a.a.

Protein Preferred Names

Protein Names

structural maintenance of chromosomes protein 6

SMC protein 6

Related Diseases

Diseases

Alias

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13422	SMC6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SMC6	MGD	MGI:1914491
Rattus norvegicus	SMC6	RGD	RGD:1311214
Bos taurus	SMC6	VGNC	VGNC:35003
Canis familiaris	SMC6	VGNC	VGNC:46547
Felis catus	SMC6	VGNC	VGNC:65480
Macaca mulatta	SMC6	VGNC	VGNC:77746