HBx-DDB1-IN-1
HBx-DDB1-IN-1 is an orally active HBx-DDB1 protein-protein interaction inhibitor and antiviral agent. HBx-DDB1-IN-1 interferes with HBx-mediated Smc5/6 degradation, thereby partially restoring Smc6 protein levels. HBx-DDB1-IN-1 can be used for the research of chronic hepatitis B virus infection.
For research use only. We do not sell to patients.
- Formula: C11H5F4N3O3S
- Molecular Weight:335.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HBx-DDB1-IN-1 (Compound 49a) (30 min) potently inhibits the interaction between HBx and DDB1 in co-transfected HEK293T cells, with an IC50 of 0.083 μM, and shows no cytotoxicity at concentrations up to 100 μM[1].
HBx-DDB1-IN-1 (1 μM; administered once every 3 days for a total of 6 days) reduces the HBV DNA level in HBV-infected HepaRG cells by approximately 30%. No obvious cytotoxicity is observed at this concentration, but higher concentrations are toxic[1].
HBx-DDB1-IN-1 (0.1-1 μM, 24 h) slightly restores SMC6 protein levels in HepG2-TO-HBx-Flag cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2-TO-HBx-Flag cells[
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Concentration:0.1, 1 μM
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Incubation Time:24 h
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Result:Slightly restored SMC6 protein levels in HepG2-TO-HBx-Flag cells.
| Species | Dose | Route | Tmax | Cmax | T1/2 | AUC0-last | AUC0-∞ | Bioavailability | CL | Vss |
|---|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 5 mg/kg | i.v. | / | / | 1.67 h | / | 54.66 μg·h/mL | / | 0.10 L/h/kg | 0.16 L/kg |
| Mice[1] | 10 mg/kg | p.o. | 0.5 h | 22.93 μg/mL | 4.82 h | 102.56 μg·h/mL | 128.18 μg·h/mL | 93.83 % | / | / |
| Rat[1] | 5 mg/kg | i.v. | / | / | 3.15 h | 63.14 μg·h/mL | 63.3 μg·h/mL | / | 0.09 L/h/kg | 0.17 L/kg |
| Rat[1] | 10 mg/kg | p.o. | 3.5 h | 14 μg/mL | 5.17 h | 119.94 μg·h/mL | 125.34 μg·h/mL | 94.97 % | / | / |
Chemical Information
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Molecular Weight 335.23
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Formula C11H5F4N3O3S
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SMILES
O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(C(F)(F)F)C(F)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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