SMC5 - structural maintenance of chromosomes 5 Gene

Homo sapiens

Also known as SMC5L1

Gene ID: 23137 | Gene type: protein coding

About SMC5

Cytogenetic location: 9q21.12 Genomic coordinates (GRCh38): 9:70,258,978-70,354,873 (from NCBI)

This gene has 4 transcripts (splice variants), 120 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 12.4), lymph node (RPKM 10.1) and 25 other tissues.

Summary

Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC5 Products(1)

mRNA	Protein	Name
NM_015110.4	NP_055925.2	structural maintenance of chromosomes protein 5

SMC5 Protein Structure

SMC_N

0
200
400
600
800
1000
1101 a.a.

Protein Preferred Names

Protein Names

structural maintenance of chromosomes protein 5

SMC protein 5

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13421	SMC5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SMC5	RGD	RGD:1307492
Bos taurus	SMC5	VGNC	VGNC:35002
Canis familiaris	SMC5	VGNC	VGNC:46546
Felis catus	SMC5	VGNC	VGNC:65479
Mus musculus	SMC5	MGD	MGI:2385088