ZNF687 - zinc finger protein 687 Gene

Also Known as PDB6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57592

About ZNF687

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,281,522-151,292,176 (from NCBI)

This gene has 7 transcripts (splice variants), 272 orthologues, 51 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 9.1), testis (RPKM 7.2) and 25 other tissues.

Summary

This gene encodes C2H2 Zinc Finger Protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

ZNF687 Products (3)

mRNA	Protein	Name
NM_001304763.2	NP_001291692.1	zinc finger protein 687
NM_001304764.2	NP_001291693.1	zinc finger protein 687
NM_020832.3	NP_065883.1	zinc finger protein 687

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF687 Protein Structure

zf-C2H2_4

zf-C2H2

0
200
400
600
800
1000
1237 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 687

ZNF687 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNF687	Q8N1G0	TSPYL2	Homo sapiens	Q9H2G4	Anti Tag CoIP	26496610
Intra	ZNF687	Q8N1G0	TSPYL2	Homo sapiens	Q9H2G4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Paget Disease Of Bone 6	PDB6 Paget Disease Of Bone, Type 6
Malignant Giant Cell Tumor	Malignant Tumor, Giant Cell Type Malignant Giant Cell Neoplasm
Intellectual Developmental Disorder, Autosomal Dominant 43	MRD43 Autosomal Dominant Non-Syndromic Intellectual Disability 43 Autosomal Dominant Intellectual Developmental Disorder 43 Autosomal Dominant Mental Retardation 43
Familial Expansile Osteolysis	FEO Mccabe Disease Osteolysis, Familial Expansile Polyostotic Osteolytic Dysplasia, Hereditary Expansile Hepod Expansile Osteolysis, Familial Eof Hereditary Expansile Polyostotic Osteolytic Dysplasia
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Chromosome 10q23 Deletion Syndrome
Macular Dystrophy, Patterned, 2	Patterned Macular Dystrophy 2 MDPT2 Macular Dystrophy, Butterfly-Shaped Pigmentary, 2 Butterfly-Shaped Pigmentary Maculary Dystrophy 2
Ritscher-Schinzel Syndrome 2	RTSC2
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Cenani-Lenz Syndactyly Syndrome	Syndactyly Type 7 Cenani Syndactylism Cenani-Lenz Syndactyly CLSS Syndactyly Cenani Lenz Type Cenani-Lenz Syndrome Syndactyly, Type Vii Cenani-Lenz Type Syndactyly Cenani Syndactyly Syndactyly Type Vii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16165	ZNF687 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZNF687	VGNC	VGNC:37328
Rattus norvegicus	ZNF687	RGD	RGD:2323182
Felis catus	ZNF687	VGNC	VGNC:67350
Macaca mulatta	ZNF687	VGNC	VGNC:79795
Canis familiaris	ZNF687	VGNC	VGNC:48795
Mus musculus	ZNF687	MGD	MGI:1925516
Others	ZNF687	NCBI