ADAM12 - ADAM metallopeptidase domain 12 Gene

Also Known as MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8038

About ADAM12

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:126,012,391-126,388,477 (from NCBI)

This gene has 7 transcripts (splice variants), 267 orthologues and 20 paralogues. Biased expression in placenta (RPKM 63.0), gall bladder (RPKM 5.5) and 2 other tissues.

Summary

This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

ADAM12 Products (5)

mRNA	Protein	Name
NM_001288973.2	NP_001275902.1	disintegrin and metalloproteinase domain-containing protein 12 isoform 3 preproprotein
NM_001288974.2	NP_001275903.1	disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein
NM_001288975.2	NP_001275904.1	disintegrin and metalloproteinase domain-containing protein 12 isoform 5 preproprotein
NM_003474.6	NP_003465.3	disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein
NM_021641.5	NP_067673.2	disintegrin and metalloproteinase domain-containing protein 12 isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	15280379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15574124	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	28637396	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15280379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM12 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
800
909 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 12	meltrin-alpha

ADAM12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAM12	O43184	AHI1	Homo sapiens	Q8N157	Peptide Array	25825872
Intra	ADAM12	O43184	AHI1	Homo sapiens	Q8N157	Phage Display	25825872
Intra	ADAM12	O43184	HCK	Homo sapiens	P08631	Phage Display	25825872
Intra	ADAM12	O43184	HCK	Homo sapiens	P08631	Peptide Array	25825872
Intra	ADAM12	O43184	SRC	Homo sapiens	P12931	Phage Display	25825872
Intra	ADAM12	O43184	SRC	Homo sapiens	P12931	Peptide Array	25825872
Intra	ADAM12	O43184	LYN	Homo sapiens	P07948	Phage Display	25825872
Intra	ADAM12	O43184	LYN	Homo sapiens	P07948	Peptide Array	25825872

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ADAM12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72814	ADAM12 Protein, Human (HEK293, His)	O43184 (R29-S513)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Benign Giant Cell Tumor	Giant Cell Tumors
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00269	ADAM12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18084	Adam12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24558	Adam12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADAM12	VGNC	VGNC:69469
Felis catus	ADAM12	VGNC	VGNC:59575
Bos taurus	ADAM12	VGNC	VGNC:25605
Rattus norvegicus	ADAM12	RGD	RGD:1583652
Canis familiaris	ADAM12	VGNC	VGNC:37574
Mus musculus	ADAM12	MGD	MGI:105378
Others	ADAM12	NCBI