Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat

  • Eur J Pharmacol. 1987 Oct 27;142(3):447-51. doi: 10.1016/0014-2999(87)90086-0.
S D Mendelson  1 ,  N Lee ,  B B Gorzalka
Affiliations
  • 1. Department of Psychology, University of British Columbia, Vancouver, Canada.
PMID: 3428356 DOI: 10.1016/0014-2999(87)90086-0
Abstract

Intraventricular administration of the tryptophan metabolites l-kynurenine (2-32 micrograms) and kynuramine (0.064-8 micrograms) facilitated lordosis behavior in estrogen-primed ovariectomized rats. The facilitatory effects of these drugs were not attenuated by pretreatment with the progesterone antagonist RU 38486, indicating that the effects were not mediated by release of adrenal progesterone. It is suggested that l-kynurenine and kynuramine may serve a physiological role in the modulation of female sexual behavior.

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