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Cat. No.: HY-125085

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ALDH3A1-IN-3

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a K_i value of 4.7 μM and an IC₅₀ value of 16 μM. ALDH3A1-IN-3 has no inhibitory potential on the in vitro activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2. ALDH3A1-IN-3 can be used in cellular oxidation and cancer research.

For research use only. We do not sell to patients.

Purity: 99.43%
CAS No.: 315239-63-5
Formula: C₁₅H₁₅N₃O₅S
Molecular Weight:349.36

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ALDH3A1-IN-3 Chemical Structure

CAS No.: 315239-63-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

ALDH3A1

16 μM (IC₅₀)

All Aldehyde Dehydrogenase (ALDH) Isoforms :

In Vitro

ALDH3A1-IN-3 (CB29) (50 μM, 3 min) significantly inhibits ALDH3A1 activity in A549 and SF767 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 315239-63-5
Appearance Solid
Molecular Weight 349.36
Formula C₁₅H₁₅N₃O₅S
Color Yellow to orange
SMILES

CC(NC1=CC=C(C=C1)NC2=CC=C(C=C2[N+]([O-])=O)S(=O)(C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Oncogene

Discovery of ferroptosis-inducing R4VP compounds for targeting aggressive cancers. [Abstract]

2026 Jul;45(27):2727-2742. PMID: 42243330

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (57.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8624 mL

14.3119 mL

28.6238 mL

5 mM

0.5725 mL

2.8624 mL

5.7248 mL

10 mM

0.2862 mL

1.4312 mL

2.8624 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Parajuli B,et al. Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity. Chembiochem. 2014 Mar 21;15(5):701-12. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8624 mL	14.3119 mL	28.6238 mL	71.5594 mL
	5 mM	0.5725 mL	2.8624 mL	5.7248 mL	14.3119 mL
	10 mM	0.2862 mL	1.4312 mL	2.8624 mL	7.1559 mL
	15 mM	0.1908 mL	0.9541 mL	1.9083 mL	4.7706 mL
	20 mM	0.1431 mL	0.7156 mL	1.4312 mL	3.5780 mL
	25 mM	0.1145 mL	0.5725 mL	1.1450 mL	2.8624 mL
	30 mM	0.0954 mL	0.4771 mL	0.9541 mL	2.3853 mL
	40 mM	0.0716 mL	0.3578 mL	0.7156 mL	1.7890 mL
	50 mM	0.0572 mL	0.2862 mL	0.5725 mL	1.4312 mL

Keywords

100 mg

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Biological Activity
- Description
- IC50 & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo Dissolution Calculator
Purity & Documentation
References

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ALDH3A1-IN-3

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Cancer Stem Cells Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) ALDH3A1-IN-3

All Aldehyde Dehydrogenase (ALDH) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

ALDH3A1-IN-3

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Glutamine Metabolism Compound Library

Anti-Cancer Metabolism Compound Library

Cancer Stem Cells Compound Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) ALDH3A1-IN-3

All Aldehyde Dehydrogenase (ALDH) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

ALDH3A1-IN-3 Related Classifications

Cat. No.: HY-125085