ANXA11 - annexin A11 Gene

Also Known as ALS23; ANX11; CAP50; CAP-50; IBMWMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 311

About ANXA11

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,150,889-80,205,808 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 36.2), heart (RPKM 32.2) and 25 other tissues.

Summary

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

ANXA11 Products (6)

mRNA Protein Name
NM_001157.3 NP_001148.1 annexin A11 isoform 1
NM_001278407.2 NP_001265336.1 annexin A11 isoform 1
NM_001278408.2 NP_001265337.1 annexin A11 isoform 1
NM_001278409.2 NP_001265338.1 annexin A11 isoform 2
NM_145868.2 NP_665875.1 annexin A11 isoform 1
NM_145869.2 NP_665876.1 annexin A11 isoform 1

ANXA11 Protein Structure

Annexin

Annexin: Annexin (204 - 269)

Annexin

Annexin: Annexin (277 - 341)

Annexin

Annexin: Annexin (359 - 424)

Annexin

Annexin: Annexin (435 - 499)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

annexin A11

  • 56 kDa autoantigen

ANXA11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ANXA11 P50995 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
ANXA11 P50995 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra
ANXA11 P50995 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra
ANXA11 P50995 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
ANXA11 P50995 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
ANXA11 P50995 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
ANXA11 P50995 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
ANXA11 P50995 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
ANXA11 P50995 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
ANXA11 P50995 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
ANXA11 P50995 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
ANXA11 P50995 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
ANXA11 P50995 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
Intra
ANXA11 P50995 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
Intra
ANXA11 P50995 FUBP1 Homo sapiens Q96AE4-2
Validated Y2H
32296183
Intra
ANXA11 P50995 ARSA Homo sapiens P15289
Y2H Prey Pooling
32296183
Intra
ANXA11 P50995 ARSA Homo sapiens P15289
Y2H Array
32296183
Intra
ANXA11 P50995 PDCD6 Homo sapiens O75340
Y2H Array
25910212
Intra
ANXA11 P50995 PDCD6 Homo sapiens O75340
Pull Down
18256029
Intra
ANXA11 P50995 PDCD6 Homo sapiens O75340
Validated Y2H
25910212
Intra
ANXA11 P50995 PDCD6 Homo sapiens O75340
Y2H Bait-Prey Pool
25910212
Intra
ANXA11 P50995 TFG Homo sapiens Q92734
Validated Y2H
25910212
Intra
ANXA11 P50995 TFG Homo sapiens Q92734
Y2H Bait-Prey Pool
25910212
Intra
ANXA11 P50995 TFG Homo sapiens Q92734
Y2H Array
25910212
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Validated Y2H
25910212
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Bait-Prey Pool
25910212
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Validated Y2H
32296183
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Array
31515488
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Array
25910212
Intra
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 23

  • Amyotrophic Lateral Sclerosis Type 23

  • ALS23
Inclusion Body Myopathy And Brain White Matter Abnormalities

  • Multisystem Proteinopathy 6

  • IBMWMA

  • Msp6
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Uveoparotid Fever

  • Heerfordt'S Syndrome
Papillary Hidradenoma

  • Tubular Sweat Gland Adenomas
Autoimmune Pancreatitis

  • Lymphoplasmocytic Sclerosing Pancreatitis

  • Aip
Hypersensitivity Reaction Type Iv Disease

  • Immunoproliferative Disorders

  • Immunoproliferative Disease
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

  • FTDALS1

  • Frontotemporal Dementia And/Or Motor Neuron Disease

  • Ftdmnd

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

  • Alsftd

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

  • Frontotemporal Dementia With Motor Neuron Disease

  • Ftdals

  • Ftd-Als

  • Ftd-Mnd

  • Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

  • Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

  • Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

  • Frontotemporal Lobar Degeneration

  • Grn-Related Frontotemporal Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00759 ANXA11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANXA11 VGNC VGNC:37938
Macaca mulatta ANXA11 VGNC VGNC:69946
Rattus norvegicus ANXA11 RGD RGD:1309911
Mus musculus ANXA11 MGD MGI:108481
Felis catus ANXA11 VGNC VGNC:67689
Bos taurus ANXA11 VGNC VGNC:25964
Others ANXA11 NCBI