SPCS3 - signal peptidase complex subunit 3 Gene

Also Known as SPC3; SPC22; SPC23; PRO3567; YLR066W; SPC22/23

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 60559

About SPCS3

Cytogenetic location: 4q34.2 Genomic coordinates (GRCh38): 4:176,319,966-176,332,245 (from NCBI)

This gene has 4 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in thyroid (RPKM 45.3), appendix (RPKM 34.4) and 25 other tissues.

Summary

Predicted to enable peptidase activity. Involved in proteolysis and viral protein processing. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SPCS3 Products (1)

mRNA Protein Name
NM_021928.4 NP_068747.1 signal peptidase complex subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25959826 GOA
Biological Process GO Annotation Evidence References Source
involved in proteolysis IDA
IDA: Inferred from direct assay
27499293 GOA
involved in signal peptide processing IDA
IDA: Inferred from direct assay
34388369 GOA
involved in viral protein processing IMP
IMP: Inferred from mutant phenotype
27383988 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
34388369 GOA
part of signal peptidase complex IPI
IPI: Inferred from physical interaction
34388369 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPCS3 Protein Structure

SPC22

SPC22: Signal peptidase subunit (1 - 175)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

signal peptidase complex subunit 3

  • SPase 22 kDa subunit

SPCS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPCS3 P61009 SEC11A Homo sapiens P67812
Anti Tag CoIP
33961781
Intra
SPCS3 P61009 SEC11C Homo sapiens Q9BY50
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Omsk Hemorrhagic Fever

  • Ohf

  • Hemorrhagic Fever, Omsk

  • Ohf - [Omsk Haemorrhagic Fever]

  • Spring-Fall Haemorrhagic Fever
Tick Infestation

  • Tick Infestations
Mixed Ductal-Endocrine Carcinoma
Yellow Fever

  • Urban Yellow Fever

  • Jungle Yellow Fever

  • Sylvatic Yellow Fever

  • Yf

  • Yellow Fever, Sylvan

  • Bronze John

  • Yellow Jack

  • Yf- [Yellow Fever]

  • Febris Flava
Parasitic Ectoparasitic Infectious Disease

  • Ectoparasitic Infestations

  • Ectoparasitism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22824 Spcs3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13651 SPCS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29339 Spcs3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SPCS3 VGNC VGNC:82299
Felis catus SPCS3 VGNC VGNC:107468
Rattus norvegicus SPCS3 RGD RGD:1588184
Macaca mulatta SPCS3 VGNC VGNC:77995
Mus musculus SPCS3 MGD MGI:1923937
Bos taurus SPCS3 VGNC VGNC:58352
Others SPCS3 NCBI