SEC11A - SEC11 homolog A, signal peptidase complex subunit Gene

Also Known as SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23478

About SEC11A

Cytogenetic location: 15q25.2-q25.3 Genomic coordinates (GRCh38): 15:84,669,544-84,716,139 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues.

Summary

This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric Cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

SEC11A Products (6)

mRNA Protein Name
NM_001271918.2 NP_001258847.1 signal peptidase complex catalytic subunit SEC11A isoform 5
NM_001271919.2 NP_001258848.1 signal peptidase complex catalytic subunit SEC11A isoform 6
NM_001271920.2 NP_001258849.1 signal peptidase complex catalytic subunit SEC11A isoform 4
NM_001271921.2 NP_001258850.1 signal peptidase complex catalytic subunit SEC11A isoform 1
NM_001271922.2 NP_001258851.1 signal peptidase complex catalytic subunit SEC11A isoform 3
NM_014300.4 NP_055115.1 signal peptidase complex catalytic subunit SEC11A isoform 2

SEC11A Protein Structure

Peptidase_S24

Peptidase_S24: Peptidase S24-like (52 - 104)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

signal peptidase complex catalytic subunit SEC11A

  • SEC11-like protein 1

SEC11A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEC11A P67812 ADAM33 Homo sapiens Q08AM2
Validated Y2H
32296183
Intra
SEC11A P67812 SPCS3 Homo sapiens P61009
Anti Tag CoIP
34388369
Intra
SEC11A P67812 SPCS3 Homo sapiens P61009
Crosslink
34388369
Intra
SEC11A P67812 SPCS3 Homo sapiens P61009
SLCA
34388369
Intra
SEC11A P67812 SPCS3 Homo sapiens P61009
Anti Tag CoIP
33961781
Intra
SEC11A P67812 SPCS3 Homo sapiens P61009
3D-EM
34388369
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12603 SEC11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SEC11A VGNC VGNC:80851
Macaca mulatta SEC11A VGNC VGNC:99235
Bos taurus SEC11A VGNC VGNC:53951
Mus musculus SEC11A MGD MGI:1929464
Rattus norvegicus SEC11A RGD RGD:69360
Canis familiaris SEC11A VGNC VGNC:53239
Others SEC11A NCBI