ELOC - elongin C Gene

Also Known as SIII; TCEB1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6921

About ELOC

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,945,119-73,972,287 (from NCBI)

This gene has 15 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in testis (RPKM 15.6), brain (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

ELOC Products (9)

mRNA	Protein	Name
NM_001204857.2	NP_001191786.1	elongin-C isoform a
NM_001204858.2	NP_001191787.1	elongin-C isoform a
NM_001204859.2	NP_001191788.1	elongin-C isoform a
NM_001204860.2	NP_001191789.1	elongin-C isoform a
NM_001204861.2	NP_001191790.1	elongin-C isoform a
NM_001204862.2	NP_001191791.1	elongin-C isoform a
NM_001204863.2	NP_001191792.1	elongin-C isoform b
NM_001204864.2	NP_001191793.1	elongin-C isoform b
NM_005648.4	NP_005639.1	elongin-C isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10205047	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	7660122	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	30166453	GOA
involved in target-directed miRNA degradation	IMP IMP: Inferred from mutant phenotype	33184237	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	7660122	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21980433	GOA
part of elongin complex	IDA IDA: Inferred from direct assay	7660122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOC Protein Structure

Skp1_POZ

0
100
112 a.a.

Protein Preferred Names	Protein Names
elongin-C	RNA polymerase II transcription factor SIII subunit C

ELOC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Validated Y2H	25416956
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Validated Y2H	32296183
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Array	32296183
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Prey Pooling	25416956
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Prey Pooling	32296183
Intra	ELOC	Q15369	METTL21C	Homo sapiens	Q5VZV1	Y2H Array	31515488
Cross	ELOC	Q15369	ORF10	SARS-CoV-2	A0A663DJA2	Y2H Array	36217030
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Validated Y2H	32296183
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Array	25416956
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Array	20211142
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Array	32296183
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H	21516116
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Pooling	16189514
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Prey Pooling	25416956
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Validated Y2H	25416956
Intra	ELOC	Q15369	ELOB	Homo sapiens	Q15370	Y2H Prey Pooling	32296183
Intra	ELOC	Q15369	PRAME	Homo sapiens	P78395	Y2H	23460923
Intra	ELOC	Q15369	PRAME	Homo sapiens	P78395	Confocal	23460923
Intra	ELOC	Q15369	MED8	Homo sapiens	Q96G25	Y2H	12149480
Intra	ELOC	Q15369	CUL2	Homo sapiens	Q13617	Pull Down	17183367
Intra	ELOC	Q15369	SOCS2	Homo sapiens	O14508	Y2H Array	16643902
Intra	ELOC	Q15369	ASB9	Homo sapiens	Q96DX5	Y2H Array	20211142
Intra	ELOC	Q15369	SOCS1	Homo sapiens	O15524	Pull Down	17183367
Cross	ELOC	Q15369	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Retinal Hemangioblastoma	Capillary Hemangioma Of Retina
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Central Nervous System Hemangioma	Hemangioma Of Cns Hemangioma Of The Central Nervous System
Erythrocytosis, Familial, 4	ECYT4 Familial Erythrocytosis 4 Erythrocytosis, Familial, Type 4
Familial Renal Papillary Carcinoma	Hereditary Papillary Renal Carcinoma Papillary Renal Cancer Hereditary
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Leiomyoma Cutis	Cutaneous Leiomyoma Leiomyoma Of The Skin
Dermis Tumor	Dermis Tumour Neoplasm Of Dermis Tumor Of Dermis Tumour Of Dermis
Erythrocytosis, Familial, 2	Chuvash Polycythemia ECYT2 Familial Erythrocytosis 2 Autosomal Recessive Benign Erythrocytosis Polycythemia, Vhl-Dependent Chuvash Erythromatosis Chuvash Type Polycythemia Chuvash Erythrocytosis Von Hippel-Lindau-Dependent Polycythemia Polycythemia Chuvash Type Vhl-Dependent Polycythemia Erythrocytosis, Familial, Type 2
Inhibited Male Orgasm	Male Orgasmic Disorder Psychosexual Dysfunction With Male Orgasmic Disorder
Primary Polycythemia	Familial Erythrocytosis Familiar Polycythemia Benign Familial Polycythemia Congenital Erythrocytosis Familial Polycythemia Hereditary Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Familial Polycythemia Vera Primary Familial Polycythaemia Primary Inherited Polycythaemia
Hereditary Renal Cell Carcinoma
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Cardiovascular Organ Benign Neoplasm
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04319	ELOC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ELOC	RGD	RGD:620658
Macaca mulatta	ELOC	VGNC	VGNC:82139
Mus musculus	ELOC	MGD	MGI:1915173
Bos taurus	ELOC	VGNC	VGNC:28445
Canis familiaris	ELOC	VGNC	VGNC:40317
Others	ELOC	NCBI