GRP75-IN-1
GRP75-IN-1 (Compound 33) is an anti-endometrial cancer (EC) agent. GRP75-IN-1 induces apoptosis in endometrial cancer cells. GRP75-IN-1 hydrochloride reduces mitochondrial Ca2+ levels by targeting GRP75 and disrupting its interaction with IP3R. GRP75-IN-1 inhibits tumor growth in human endometrial cancer xenograft animal models. GRP75-IN-1 can be used for research in endometrial cancer.
For research use only. We do not sell to patients.
- CAS No.: 2922680-16-6
- Formula: C27H38N4OS
- Molecular Weight:466.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Ishikawa | IC50 |
0.99 μM
Compound: 33
|
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 39082833] |
| KLE | IC50 |
3.18 μM
Compound: 33
|
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 39082833] |
Chemical Information
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CAS No. 2922680-16-6
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Molecular Weight 466.68
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Formula C27H38N4OS
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SMILES
CN1CCC2(CCN(CC2)CCCCCN3C4=C(SC5=CC=C(C=C53)OC)C=CC=N4)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)