L 743310
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis.
For research use only. We do not sell to patients.
- CAS No.: 187724-86-3
- Formula: C30H33BrF6N4O2
- Molecular Weight:675.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
hNK1 receptor[1]
Chemical Information
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CAS No. 187724-86-3
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Molecular Weight 675.50
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Formula C30H33BrF6N4O2
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SMILES
C[N+]1(CC2)CCC2(NC(NC(CC3=CNC4=C3C=CC=C4)C(CCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)=O)CC1.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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