187724-86-3
Chemical Structure
L 743310
- CAS No.: 187724-86-3
- Formula:C30H33BrF6N4O2
- Molecular Weight:675.50
IUPAC Name: 4-(3-(5-(3,5-bis(trifluoromethyl)phenyl)-1-(1H-indol-3-yl)-3-oxopentan-2-yl)ureido)-1-methylquinuclidin-1-ium bromide
InChIKey: AQFXPXNYLQHPJX-UHFFFAOYSA-N
SMILES: C[N+]1(CC2)CCC2(NC(NC(CC3=CNC4=C3C=CC=C4)C(CCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)=O)CC1.[Br-]
Biological Activity: L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis[1].
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L 743310 | L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis. | |||||||||||||||||||||
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