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Cat. No.: HY-130705

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Previtamin D3

Previtamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism.

For research use only. We do not sell to patients.

CAS No.: 1173-13-3
Formula: C₂₇H₄₄O
Molecular Weight:384.64

Storage:

-80°C, protect from light, stored under nitrogen

Previtamin D3 Chemical Structure

CAS No.: 1173-13-3

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Previtamin D3 undergoes temperature-dependent first-order interconversion with vitamin D₃ in ethanol, with faster isomerization at higher temperatures^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Previtamin D3 (0.2 J/cm²; topical skin exposure; single dose) Exposure of vitamin-D-deficient rat skin converts cutaneous 7-dehydrocholesterol to previtamin D₃, which does not thermally isomerize to vitamin D₃ under low-temperature processing conditions^[1].
Previtamin D3 (28-111 μg/1000 g consumed diet; p.o.; 7 doses at 3 to 4 day intervals) exhibits 35% of the antirachitic activity of pure vitamin D3 in rachitic North Holland Blue chicks, with this activity hypothesized to originate exclusively from vitamin D3 formed via in vivo isomerization^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Vitamin-D-deficient rats^[1]
Dosage:

0.2 J/cm²
Administration:

topical skin exposure; single dose
Result:

Identified radiolabeled previtamin D3 as the main photoproduct in UV-exposed skin extracts, with no vitamin D3 detected right after irradiation.
Verified previtamin D3 using mass spectrometry and UV spectroscopy, and validated its thermal conversion to vitamin D3 via characteristic spectral changes.

Animal Model:

North Holland Blue (1-day-old, mixed sex, weight-homogeneous groups, rachitogenic diet-induced rickets)^[2]
Dosage:

28 μg/1000 g consumed diet; 44 μg/1000 g consumed diet; 70 μg/1000 g consumed diet; 111 μg/1000 g consumed diet
Administration:

p.o.; 7 doses at 3 to 4 day intervals
Result:

Recorded dose-dependent reductions in mean t.m.t.-distance values in chick assays, and displayed an antirachitic activity ratio of 0.35 (95% CI, 0.29-0.42) relative to pure vitamin D3.

Chemical Information

CAS No. 1173-13-3
Appearance Oil
Molecular Weight 384.64
Formula C₂₇H₄₄O
Color Colorless to light yellow
SMILES

O[C@@H]1CC(/C=C\C2=CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]23[H])=C(C)CC1
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Holick MF, et al. The cutaneous photosynthesis of previtamin D3: a unique photoendocrine system. J Invest Dermatol. 1981;77(1):51-58. [Content Brief]

[2]. Hanewald KH, et al. The antirachitic activity of previtamin D3. Recl Trav Chim Pays-Bas. 1961;80(9):1003-1014.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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