2',5'-Dideoxy-3'-ATP
2',5'-Dideoxy-3'-ATP is an adenylate cyclase inhibitor. 2',5'-Dideoxy-3'-ATP exerts linear noncompetitive inhibition via binding to the distinct P-site. 2',5'-Dideoxy-3'-ATP binds and stabilizes the dimeric form of Mycobacterium avium adenylyl cyclase Ma1120 to inhibit activity.
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- CAS 番号: 162554-02-1
- 分子式: C10H16N5O11P3
- 分子量:475.18
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
2',5'-Dideoxy-3'-ATP potently inhibits rat brain adenylyl cyclase with an IC50 of 40 nM[1].
2',5'-Dideoxy-3'-ATP inhibits purified bovine brain adenylyl cyclase with an IC50 of 120 nM[1].
2',5'-Dideoxy-3'-ATP directly inhibits purified recombinant Type I adenylyl cyclase (from Sf9 cells) with an IC50 of 170 nM[1].
2',5'-Dideoxy-3'-ATP (3 min) potently inhibits Forskolin (HY-15371)-stimulated activity of purified wild-type adenylyl cyclase (wt-AC) with a Ki of 200 nM in a fluorescence-based cyclase assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 162554-02-1
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分子量 475.18
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分子式 C10H16N5O11P3
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3C[C@H](OP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](C)O3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Désaubry L, et al. 2',5'-Dideoxyadenosine 3'-polyphosphates are potent inhibitors of adenylyl cyclases. J Biol Chem. 1996 Feb 2;271(5):2380-2. [Content Brief]
[2]. Vadakkadathmeethal K, et al. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Comb Chem High Throughput Screen. 2007;10(4):289-298. [Content Brief]
[3]. Barathy DV, et al. Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase. J Struct Biol. 2015;190(3):304-313. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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