3079942-94-9
Chemical Structure
CC-11
- CAS 番号: 3079942-94-9
- Formula:C52H54F2N12O10S
- Molecular Weight:1077.12
InChIKey: ZJXAKCJFIWLLOQ-UHFFFAOYSA-N
SMILES: CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C
Biological Activity: CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer[1].
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CC-11 | CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer. | |||||||||||||||||||||
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Keywords
