ACTR3 - actin related protein 3 Gene

Also Known as ARP3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10096

About ACTR3

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,889,934-113,962,596 (from NCBI)

This gene has 8 transcripts (splice variants), 249 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 65.6), appendix (RPKM 59.7) and 24 other tissues.

Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

ACTR3 Products (2)

mRNA Protein Name
NM_001277140.1 NP_001264069.1 actin-related protein 3 isoform 2
NM_005721.5 NP_005712.1 actin-related protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
contributes to actin filament binding IDA
IDA: Inferred from direct assay
11741539 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
11741539 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in Arp2/3 complex-mediated actin nucleation IDA
IDA: Inferred from direct assay
11741539 GOA
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
20393563 GOA
involved in positive regulation of lamellipodium assembly IDA
IDA: Inferred from direct assay
29058690 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17220302 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of Arp2/3 protein complex IDA
IDA: Inferred from direct assay
11741539 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17220302 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
9230079 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16767080 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR3 Protein Structure

Actin

Actin: Actin (6 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

actin-related protein 3

  • ARP3 actin related protein 3 homolog

ACTR3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ACTR3 P61158 CENPH Homo sapiens Q9H3R5
Y2H Array
32814053
Intra
ACTR3 P61158 CENPH Homo sapiens Q9H3R5
Y2H Pooling
32814053
Intra
ACTR3 P61158 CENPH Homo sapiens Q9H3R5
Validated Y2H
32814053
Intra
ACTR3 P61158 CDK5 Homo sapiens Q00535
Y2H Pooling
32814053
Intra
ACTR3 P61158 CDK5 Homo sapiens Q00535
Validated Y2H
32814053
Intra
ACTR3 P61158 CDK5 Homo sapiens Q00535
Y2H Array
32814053
Intra
ACTR3 P61158 BRPF3 Homo sapiens Q9ULD4-2
Y2H Pooling
32814053
Intra
ACTR3 P61158 BRPF3 Homo sapiens Q9ULD4-2
Validated Y2H
32814053
Intra
ACTR3 P61158 BRPF3 Homo sapiens Q9ULD4-2
Y2H Array
32814053
Intra
ACTR3 P61158 UNG Homo sapiens P13051-2
Y2H Pooling
32814053
Intra
ACTR3 P61158 UNG Homo sapiens P13051-2
Validated Y2H
32814053
Intra
ACTR3 P61158 APH1A Homo sapiens Q96BI3-2
Validated Y2H
32814053
Intra
ACTR3 P61158 APH1A Homo sapiens Q96BI3-2
Y2H Pooling
32814053
Intra
ACTR3 P61158 APH1A Homo sapiens Q96BI3-2
Y2H Array
32814053
Intra
ACTR3 P61158 JUND Homo sapiens P17535
TAP
20195357
Intra
ACTR3 P61158 HSPD1 Homo sapiens P10809
Y2H Array
32814053
Intra
ACTR3 P61158 HSPD1 Homo sapiens P10809
Y2H Pooling
32814053
Intra
ACTR3 P61158 HSPD1 Homo sapiens P10809
Validated Y2H
32814053
Intra
ACTR3 P61158 STUB1 Homo sapiens Q9UNE7
Validated Y2H
32814053
Intra
ACTR3 P61158 STUB1 Homo sapiens Q9UNE7
Y2H Array
32814053
Intra
ACTR3 P61158 STUB1 Homo sapiens Q9UNE7
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACTR3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P76733 ARP3/ACTR3 Protein, Human (sf9, His-GST) P61158 (A2-S418) ≥ 90%, as determined by reducing SDS-PAGE.

ACTR3 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82010 Actin Related Protein 3 Antibody (YA1755) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P84421 Actin Related Protein 3 Antibody (YA4118) WB, IHC-P, FC, ELISA Human, Mouse
HY-P84421A Actin Related Protein 3 Antibody (YA4118)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse
HY-P84422 Actin Related Protein 3 Antibody (YA4119) WB, IHC-P, ICC/IF, ELISA Human, Mouse
HY-P84422A Actin Related Protein 3 Antibody (YA4119)(PBS only) WB, IHC-P, ICC/IF, ELISA Human, Mouse
HY-P85840 Actin Related Protein 3 Antibody (YA5532) WB, ICC/IF, ELISA Human, Mouse, Rat

関連疾患

Diseases Alias
Wiskott-Aldrich Syndrome

  • WAS

  • Eczema-Thrombocytopenia-Immunodeficiency Syndrome

  • Immunodeficiency 2

  • Aldrich Syndrome

  • Imd2

  • Wiskott-Aldrich Syndrome 1

  • Was1

  • Wiskott Syndrome

  • Wiskott Aldrich Syndrome

  • Eczema Thrombocytopenia Immunodeficiency Syndrome

  • Imd 2
Myopathy, Centronuclear, 2

  • Myopathy, Centronuclear, Autosomal Recessive

  • Autosomal Recessive Centronuclear Myopathy

  • CNM2

  • Centronuclear Myopathy 2

  • Ar-Cnm

  • Myotubular Myopathy, Autosomal Recessive

  • Autosomal Recessive Myotubular Myopathy

  • Centronuclear Myopathy Autosomal Recessive

  • Myopathy, Centronuclear, Type 2
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

  • HNPCC2

  • Fcc2

  • Coca2

  • Hereditary Nonpolyposis Colorectal Cancer Type 2

  • Colon Cancer, Familial Nonpolyposis, Type 2

  • Familial Nonpolyposis Colon Cancer Type 2

  • Hereditary Non-Polyposis Colorectal Cancer 2

  • Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS00231 ACTR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00232 ACTR3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19403 Actr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25895 Actr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus ACTR3 VGNC VGNC:50033
Felis catus ACTR3 VGNC VGNC:59557
Macaca mulatta ACTR3 VGNC VGNC:69436
Canis familiaris ACTR3 VGNC VGNC:59392
Rattus norvegicus ACTR3 RGD RGD:71024
Mus musculus ACTR3 MGD MGI:1921367
Others ACTR3 NCBI