Col1a2 - collagen, type I, alpha 2 Gene

Also Known as oim; Cola2; Cola-2; Col1a-2

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 12843

Summary

This gene encodes the alpha-2 subunit of the fibril-forming type I Collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-1 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice harboring certain mutations in the encoded gene exhibit symptoms of moderate to severe forms of osteogenesis imperfecta. [provided by RefSeq, Dec 2015]

Col1a2 Products (1)

mRNA Protein Name
NM_007743.3 NP_031769.2 collagen alpha-2(I) chain preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables SMAD binding IPI
IPI: Inferred from physical interaction
14559231 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7629088 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
22910579 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within collagen metabolic process IMP
IMP: Inferred from mutant phenotype
22910579 MGI
acts upstream of or within extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
22910579 MGI
acts upstream of or within protein heterotrimerization IDA
IDA: Inferred from direct assay
9213002 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
part of collagen trimer IDA
IDA: Inferred from direct assay
8686743 MGI
part of collagen type I trimer IDA
IDA: Inferred from direct assay
7825727 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
34368841 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
20053668 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-2(I) chain

  • alpha-2 type I collagen

  • collagen COL1A2

  • procollagen, type I, alpha 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-179410 Galectin-3-IN-7 Inhibitor / Unkown
HY-RS02971 COL1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20147 Col1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26651 Col1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Col1a2 NCBI NCBI:1278