Galectin-3-IN-7
Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a Kd of 5.7 nM and shows 390-fold selectivity over Gal-1. Galectin-3-IN-7 can downregulate profibrotic signaling such as ACTA2, COL1A2, and FN1 in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 can be used for the research of fibrosis.
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- 화학식: C31H34FN5O11S
- 분자량:703.69
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
[1]|
Galectin-3 5.7 nM (Kd) |
In Vitro
Galectin-3-IN-7 (Compound 11) exhibits moderate plasma protein binding rates of 45%, 43%, and 90% in human, mouse, and rat plasma respectively[1].
Galectin-3-IN-7 (3.7-300 μM, 24 h) shows a CC50 of >300 μM against HEK293, HepG2, THP-1, Jurkat E6.1 and LX2 cells[1].
Galectin-3-IN-7 (3.7-300 μM, 24 h) does not significantly inhibit LPS (HY-D1056)-induced TNFα secretion in THP-1 macrophage-like cells[1].
Galectin-3-IN-7 (3.7-300 μM, 48 h) dose-dependently downregulates the mRNA expression of ACTA2, COL1A2, and FN1 in TGFβ1-stimulated LX2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LX2 cells
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Concentration:3.7, 11.1, 33.3, 100 and 300 μM
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Incubation Time:48 h
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Result:Reduced the mRNA expression of ACTA2, COL1A2, and FN1.
Chemical Information
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분자량 703.69
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화학식 C31H34FN5O11S
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SMILES
O=C(C1=CC2=C(C(N([C@H]3[C@H](O)[C@@H](O)[C@H](S[C@H]4[C@H](O)[C@@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[C@@H](O)[C@@H](CO)O4)[C@@H](CO)O3)C(C)=O)=C1)C=CN2)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galectin-3-IN-7 Related Classifications
HY-179410 Related Classifications
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