Galectin-3-IN-7 

Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a K_d of 5.7 nM and shows 390-fold selectivity over Gal-1. Galectin-3-IN-7 can downregulate profibrotic signaling such as ACTA2, COL1A2, and FN1 in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 can be used for the research of fibrosis^[1].

Galectin-3-IN-7 (Compound 11) exhibits moderate plasma protein binding rates of 45%, 43%, and 90% in human, mouse, and rat plasma respectively^[1].
Galectin-3-IN-7 (3.7-300 μM, 24 h) shows a CC₅₀ of >300 μM against HEK293, HepG2, THP-1, Jurkat E6.1 and LX2 cells^[1].
Galectin-3-IN-7 (3.7-300 μM, 24 h) does not significantly inhibit LPS (HY-D1056)-induced TNFα secretion in THP-1 macrophage-like cells^[1].
Galectin-3-IN-7 (3.7-300 μM, 48 h) dose-dependently downregulates the mRNA expression of ACTA2, COL1A2, and FN1 in TGFβ1-stimulated LX2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

703.69

C₃₁H₃₄FN₅O₁₁S

O=C(C1=CC2=C(C(N([C@H]3[C@H](O)[C@@H](O)[C@H](S[C@H]4[C@H](O)[C@@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[C@@H](O)[C@@H](CO)O4)[C@@H](CO)O3)C(C)=O)=C1)C=CN2)O

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• [1]. Zýka J, et al. N-Aryl-N-Lactosylamides as Potent and Highly Selective Inhibitors of Galectin-3 with Antifibrotic Activity. J Med Chem. 2025;68(22):24624-24648.  [Content Brief]