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製品番号: HY-169296

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IMPDH2-IN-4

IMPDH2-IN-4 (Compound 2d) is a selective IMPDH2 inhibitor with a K_i,app value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₅H₃₄O₆Si
分子量:578.73

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

IMPDH2-IN-4 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

IMPDH2

1.8 μM (Ki app)

体外実験

IMPDH2-IN-4 (0.1-100.0 μM for hFOB; 72 h) potently inhibits the viability of 143B, MNNG/HOS, U2OS and SaOS-2 osteosarcoma cells, with IC₅₀ values ranging from 0.64 to 2.27 μM, while exhibiting low cytotoxicity toward normal osteoblastic hFOB 1.19 cells^[1].
IMPDH2-IN-4 inhibits recombinant IMPDH2 with a K_i,app of 1.8 μM, and does not inhibit IMPDH1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

143B, MNNG/HOS, U2OS, SaOS-2, hFOB 1.19
Concentration:

0.1 μM, 1.0 μM, 10.0 μM, 100.0 μM for hFOB 1.19
Incubation Time:

72 h
Result:

Inhibited viability of 143B cells with an IC₅₀ of 1.65 μM.
Inhibited viability of MNNG/HOS cells with an IC₅₀ of 0.64 μM.
Inhibited viability of U2OS cells with an IC₅₀ of 1.01 μM.
Inhibited viability of SaOS-2 cells with an IC₅₀ of 2.27 μM.
Reduced hFOB 1.19 cell viability to 93.91% at 0.1 μM, 91.95% at 1.0 μM, 84.5% at 10.0 μM, and 73.34% at 100.0 μM.

化学情報

分子量 578.73
分子式 C₃₅H₃₄O₆Si
SMILES

O=C(O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC/C(C)=C/CC4=C(O)C5=C(COC5=O)C(C)=C4OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Silalai P, et al. Design and Synthesis of Mycophenolic Acid Analogues for Osteosarcoma Cancer Treatment. ACS Bio Med Chem Au. 2024;5(1):106-118. Published 2024 Oct 17. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

お問い合わせ在庫あり

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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製品番号:
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IMPDH2-IN-4

High-Throughput Bioactive Compound Library

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

IMPDH2-IN-4 関連分類

HY-169296 関連分類