Lithium orotate
Based on 1 Customer Validation
Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 5266-20-6
- 分子式: C5H3LiN2O4
- 分子量:162.03
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Bioactive Compound Library
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生物活性
Lithium orotate (0-500 μM; 16 h) has low binding ability to synthetic human Aβ1-42 fibrils and oligomers[2].
Lithium orotate (20-500 μM; 6 h pre-treatment) promotes microglial uptake and degradation of Aβ42 in BV2 microglial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3xTg mice carried APPSwe and tauP301L
mutant transgenes and ageing wild-type mice[2] -
Dosage:4.3 and 130 µM
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Administration:p.o.; in drinking water
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Result:Almost completely prevented Aβ plaque deposition and phospho-tau accumulation in 3xTg mice.
Reversed memory loss in 3xTg mice and improved.
Prevented age-related microgliosis, astrogliosis, synapse loss, and cognitive decline in wild-type mice.
化学情報
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CAS 番号 5266-20-6
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性状 Solid
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分子量 162.03
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分子式 C5H3LiN2O4
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SMILES
O=C1C=C(C(O[Li])=O)NC(N1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lithium orotate 関連分類
HY-W841438 関連分類
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