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製品番号: HY-174827

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POLRMT-IN-2

POLRMT-IN-2 is a potent POLRMT inhibitor. POLRMT-IN-2 exhibits strong antiproliferative activity in MOLM-13 cells, with an IC₅₀ of 1.01 μM. POLRMT-IN-2 disrupts mitochondrial function and induces apoptosis in MOLM-13cells. POLRMT-IN-2 can be used for the study of acute myeloid leukemia(AML).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₄H₃₂N₄O₅
分子量:576.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

POLRMT-IN-2 構造式

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

POLRMT-IN-2 (Compound 10a) (0-100 μM, 48 h) inhibits POLRMT activity dose-dependently in MOLM-13 cells, with an EC₅₀ value of 2.208 μΜ for ND1 expression suppression^[1].

POLRMT-IN-2 (48 h) shows anti-proliferation activity in cells with IC₅₀s of 1.01 μΜ (MOLM-13 cells), 3.24 μΜ (MV4-11 cells) and 14.17 μΜ (HL-60 cells)^[1].

POLRMT-IN-2 (5 μM, 48 h) can inhibit the proliferation of MOLM-13 cells, as evidenced by the reduction in EdU-positive cells and decreased Ki67 expression^[1].

POLRMT-IN-2 (0-10 μM, 48 h) disrupts mitochondrial function in MOLM-13 cells, as demonstrated by dose-dependent increases in ROS levels, decreases in ATP content, and reduction of mitochondrial membrane potential^[1].

POLRMT-IN-2 (0-10 μM, 48 h) induces apoptosis and reduces the expression of both AKT and p-AKTSer473 in MOLM-13 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

MOLM 13 cells
Concentration:

5 μM
Incubation Time:

48 h
Result:

Increased the positive areas of tunel staining.

Western Blot Analysis^[1]

Cell Line:

MOLM 13 cells
Concentration:

0, 2.5, 5, 10 μM
Incubation Time:

48 h
Result:

Increased the expression of apoptosis marker Bax significantly.
Decreased the expression of Bcl-2 was significantly.

化学情報

分子量 576.64
分子式 C₃₄H₃₂N₄O₅
SMILES

CC1=CC=C(C(C)=C1)C2=CC(OC3=C2C=CC(O[C@@H](C(N4C5CN(C(NC6=CC=CC(C#N)=C6)=O)CC4CC5)=O)C)=C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu T, Cheng X, Wang Y, Hao W, Wang H, Zhang K, Wang J. Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia. Chem Biol Drug Des. 2025 May;105(5):e70127. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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